Department of Anesthesiology, Henan Province People's Hospital, Zhengzhou, China.
Department of Cardiology, Fuwai Central Cardiovascular Hospital, Henan Provincial People's Hospital, Zhengzhou, China.
Drug Deliv. 2021 Dec;28(1):285-292. doi: 10.1080/10717544.2020.1870021.
In relieving local pains, lidocaine, one of ester-type local anesthetics, has been used. To develop the lidocaine membranes of enhanced local anesthetic effects, we have designed to establish the composition of wound dressings based on lidocaine chloride (LCH) (anesthetic drug)-loaded chitosan (CS)/polymyxin B sulfate (PMB). The LCH membranes (LCH-CS/PMB) was fabricated by the LCH oxide solutions within the CS/PMB matrix. The influences of different experimental limitations on CS/PMB membrane formations were examined. The double membrane particle sizes were evaluated by scanning electron microscopy (HR-SEM). Additionally, antibacterial efficacy was developed for gram-positive and negative microorganisms. Moreover, we examined healing of skin wounds formed in mouse models over 16 days. In contrast to the untreated wounds, rapid healing was perceived in the LCH-CS/PMB-treated wound with less damaging. These findings indicate that LCH-CS/PMB-based bandaging materials could be a potential innovative biomaterial for tissue repair and regeneration for wound healing applications in an animal model.
在缓解局部疼痛方面，局部麻醉药利多卡因（酯类局部麻醉药之一）已被应用。为了提高利多卡因的局部麻醉效果，我们设计了以利多卡因盐酸盐（LCH）（麻醉药物）负载壳聚糖（CS）/硫酸多粘菌素 B（PMB）为基础的伤口敷料的组成。LCH 膜（LCH-CS/PMB）是通过 CS/PMB 基质中的 LCH 氧化物溶液制备的。考察了不同实验限制因素对 CS/PMB 膜形成的影响。通过扫描电子显微镜（HR-SEM）评估了双层膜的粒径。此外，还研究了对革兰氏阳性和阴性微生物的抗菌效果。此外，我们还在 16 天的时间里检查了小鼠模型中皮肤伤口的愈合情况。与未处理的伤口相比，LCH-CS/PMB 处理的伤口愈合更快，损伤更小。这些发现表明，LCH-CS/PMB 基包扎材料可能是一种有潜力的新型生物材料，可用于组织修复和再生，以促进动物模型中的伤口愈合。
