预测 P2RX7 rs3751143 多态性与癌症风险相关：荟萃分析和系统评价。
Predicted the P2RX7 rs3751143 polymorphism is associated with cancer risk: a meta-analysis and systematic review.
机构信息
Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology, Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, PR China.
出版信息
Biosci Rep. 2021 Feb 26;41(2). doi: 10.1042/BSR20193877.
BACKGROUND
Both meta-analyses and systematic reviews were used to assess the relationship between purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) rs3751143 polymorphism and the risk of cancer.
MATERIALS AND METHODS
The data used in this research were collected from Google Scholar, Web of Science, CNKI, and Wan Fang Data databases. The final retrieval ended on 22 February 2019. The strength of correlation was assessed using odds ratios and 95% confidence intervals. Based on the heterogeneity test results, fixed-effect (Mantel-Haenszel) or random-effects (DerSimonian-Laird) models were selected to summarise the collective effects.
RESULTS
Eight separate studies containing 1462 cancer cases and 3037 controls were enrolled. Overall, there was no significant association between P2RX7 rs3751143 polymorphism and the risk of cancer in the allelic, homozygous, heterozygous, dominant, or recessive models.
CONCLUSIONS
Our meta-analysis indicates that there is no significant association between P2RX7 rs3751143 polymorphism and the risk of cancer in the allelic, homozygous, heterozygous, dominant, and recessive models.
背景
荟萃分析和系统评价均被用于评估嘌呤能受体 P2X 配体门控离子通道 7（P2RX7）rs3751143 多态性与癌症风险之间的关系。
材料与方法
本研究数据来自 Google Scholar、Web of Science、CNKI 和万方数据库。最终检索截止日期为 2019 年 2 月 22 日。使用比值比和 95%置信区间评估相关性强度。根据异质性检验结果，选择固定效应（Mantel-Haenszel）或随机效应（DerSimonian-Laird）模型来总结总体效应。
结果
共纳入 8 项独立研究，包含 1462 例癌症病例和 3037 例对照。总体而言，P2RX7 rs3751143 多态性与癌症的风险在等位基因、纯合子、杂合子、显性和隐性模型中均无显著相关性。
结论
我们的荟萃分析表明，P2RX7 rs3751143 多态性与癌症的风险在等位基因、纯合子、杂合子、显性和隐性模型中均无显著相关性。
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