Cui Shumao, Jiang Jie, Li Bowen, Ross R Paul, Stanton Catherine, Zhao Jianxin, Zhang Hao, Yang Bo, Chen Wei
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China and School of Food Science and Technology, Jiangnan University, Wuxi, China.
International Joint Research Laboratory for Pharmabiotics & Antibiotic Resistance, Jiangnan University, Wuxi, China and APC Microbiome Ireland, University College Cork, Cork, Ireland.
Food Funct. 2021 Mar 1;12(4):1695-1707. doi: 10.1039/d0fo02948c.
The role of Pediococcus pentosaceus in the gastrointestinne has received considerable attention in recent decades. This study aimed to investigate the effects of the short-term administration of P. pentosaceus on physiological characteristics, inflammation, and intestinal microecology in mice. In this study, 90 male C57BL/6J mice were divided into 15 groups, with 14 groups treated with a daily intragastric administration of different genotypes of P. pentosaceus. After three weeks of intragastric administration P. pentosaceus had a mild effect on mice. It could be seen that different P. pentosaceus strains had different effects on the gut microbiota and intestinal microecology. P. pentosaceus VCQYC5144M12 possessing an Enterolysin A operon may have been harmful, activating the expression of inflammatory factors, while P. pentosaceus DYNDL69M8 consisting of only a pediocin-like operon increased the abundance of beneficial bacteria and increased the content of acetic acid. The presence of various genotypes of bacteriocin may have been the explanation for variations among strains. This may provide theoretical support for further exploring the probiotic effect and patterns of P. pentosaceus.
近几十年来，戊糖片球菌在胃肠道中的作用受到了相当大的关注。本研究旨在探讨短期给予戊糖片球菌对小鼠生理特征、炎症和肠道微生态的影响。在本研究中，90只雄性C57BL/6J小鼠被分为15组，其中14组每天通过胃内给药不同基因型的戊糖片球菌。胃内给药三周后，戊糖片球菌对小鼠有轻微影响。可以看出，不同的戊糖片球菌菌株对肠道微生物群和肠道微生态有不同的影响。具有肠溶素A操纵子的戊糖片球菌VCQYC5144M12可能是有害的，它激活了炎症因子的表达，而仅由类片球菌素操纵子组成的戊糖片球菌DYNDL69M8增加了有益细菌的丰度并增加了乙酸含量。各种基因型细菌素的存在可能是菌株间差异的原因。这可能为进一步探索戊糖片球菌的益生菌作用和模式提供理论支持。
