Institute of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Korytkova 2, Ljubjana, 1000, Slovenia.
Institute of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Korytkova 2, Ljubjana, 1000, Slovenia.
Chem Biol Interact. 2021 Mar 1;337:109399. doi: 10.1016/j.cbi.2021.109399. Epub 2021 Jan 24.
Diabetes mellitus (DM), a non-communicable endocrine disease that is marked by a differing degree of tolerance to insulin and dysfunction. The connection between diabetes and liver failure important to doctors in general practice diabetologists and hepatologists. DM is linked with an elevated risk of hepatic consequences and mortality of liver cirrhosis patients. DM may facilitate to insult the liver by inducing inflammation and fibrosis by elevating mitochondrial oxidative stress. The conventional liver function indices are bilirubin including Indirect Bilirubin (IBil), Direct Bilirubin (DBil), and Total Bilirubin (TBil). DBil, IBil, and TBil, have diverse clinical implications as the standard index of liver disorder. An elevated level of DBil may suggest damage to the hepatic cell whereas TBil is within the normal range. Thus, increased liver enzymes are correlated with hepatic insulin resistance in healthy subjects. Notably, a significant correlation between DBil levels and Insulin resistance risk could indicate a connection between liver dysfunction and diabetes mellitus risk. Thus, our primary goal via the current review to examine the impact of dietary vitamin D (VitD) in serum mediated risk reduction of insulin resistance and further incidence of DM through inflammatory liver associated high DBil. Therefore, modifying these inflammatory pathways may be a therapeutic alternative approach for diabetes treatment.
糖尿病（DM）是一种非传染性内分泌疾病，其特征是对胰岛素的不同程度耐受和功能障碍。糖尿病与肝功能衰竭之间的联系对一般实践中的医生、糖尿病学家和肝病学家都很重要。DM 会增加肝脏后果的风险，并增加肝硬化患者的死亡率。DM 可通过诱导炎症和纤维化来增加线粒体氧化应激，从而损害肝脏。传统的肝功能指数包括胆红素，包括间接胆红素（IBil）、直接胆红素（DBil）和总胆红素（TBil）。DBil、IBil 和 TBil 作为肝功能障碍的标准指标具有不同的临床意义。DBil 水平升高可能表明肝实质细胞受损，而 TBil 在正常范围内。因此，健康受试者中升高的肝酶与肝胰岛素抵抗相关。值得注意的是，DBil 水平与胰岛素抵抗风险之间的显著相关性表明，肝功能障碍与糖尿病风险之间存在关联。因此，我们通过目前的综述，主要目的是研究血清中维生素 D（VitD）对胰岛素抵抗风险降低的影响，以及通过与炎症相关的高 DBil 进一步发生 DM。因此，改变这些炎症途径可能是治疗糖尿病的一种治疗选择。
