Reitsema Vera A, Oosterhof Marloes M, Henning Robert H, Bouma Hjalmar R
Department Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Department Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Internal Medicine, Section Acute Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Dev Comp Immunol. 2021 Jun;119:104024. doi: 10.1016/j.dci.2021.104024. Epub 2021 Jan 24.
Hibernation consists of alternating periods of reduced metabolism (torpor) with brief periods of metabolism similar to summer euthermia (arousal). The function of the innate immune system is reduced during hibernation, of which the underlying mechanisms are incompletely understood. Here, we studied neutrophil functionality during hibernation in Syrian hamsters. The inflammatory response to LPS-induced endotoxemia is inhibited in hibernation, partly mediated by reduced IL-6 production in early arousal. Furthermore, neutrophil pathogen binding, phagocytosis and oxidative burst is profoundly reduced in early arousal. Functionality of both summer and early arousal neutrophils was repressed in plasma from early arousal and mixed plasma from early arousal and summer euthermic, but restored by summer euthermic plasma, signifying that a plasma factor in early arousal inhibits TLR-recognition. Identification of the inhibiting factor may offer a target to modulate neutrophil function with relevance to (auto-)inflammatory diseases.
冬眠由代谢降低（蛰伏）的交替期和与夏季正常体温（觉醒）相似的短暂代谢期组成。冬眠期间先天免疫系统的功能会降低，其潜在机制尚未完全了解。在此，我们研究了叙利亚仓鼠冬眠期间中性粒细胞的功能。对脂多糖诱导的内毒素血症的炎症反应在冬眠期间受到抑制，部分是由觉醒早期白细胞介素-6产生减少介导的。此外，在觉醒早期，中性粒细胞与病原体的结合、吞噬作用和氧化爆发显著降低。夏季和觉醒早期中性粒细胞的功能在觉醒早期血浆以及觉醒早期和夏季正常体温混合血浆中均受到抑制，但夏季正常体温血浆可使其恢复，这表明觉醒早期的一种血浆因子会抑制Toll样受体（TLR）识别。鉴定这种抑制因子可能为调节与（自身）炎症性疾病相关的中性粒细胞功能提供一个靶点。
