Herbert Wertheim School of Public Health and Human Longevity Science, UC San Diego, La Jolla, CA, USA; UC San Diego Moores Cancer Center, UC San Diego, La Jolla, CA, USA.
Herbert Wertheim School of Public Health and Human Longevity Science, UC San Diego, La Jolla, CA, USA; UC San Diego Moores Cancer Center, UC San Diego, La Jolla, CA, USA.
Contemp Clin Trials. 2021 Mar;102:106289. doi: 10.1016/j.cct.2021.106289. Epub 2021 Jan 24.
Difficulties with cognition are extremely common among breast cancer survivors and can significantly impact quality of life, daily functioning, and ability to return to work. One promising intervention is increasing physical activity, as it has been effective in improving cognition in non-cancer populations. Few physical activity intervention trials with cognition outcomes have included cancer survivors. This project builds upon our previous work indicating that increased physical activity can improve objectively measured processing speed and self-reported cognition among breast cancer survivors.
The I Can! study will examine whether a physical activity intervention improves cognition among 250 post-treatment breast cancer survivors (Stages I-III, <5 years post-treatment) who are reporting cognitive difficulties. This 2-arm randomized controlled trial comparing a 6-month physical activity intervention (Exercise Group) to a health & wellness attention-comparison condition (Health & Wellness Group) will examine intervention effects on cognition (at 3 and 6 months) and maintenance of effects at 12 months. The primary aim is to investigate the impact of exercise on objectively measured processing speed and self-reported cognition. Secondary aims are to investigate maintenance of cognitive changes and examine candidate biological mechanisms and psychological mediators.
The I Can! study will contribute to the scientific, public health, and survivorship intervention literature by providing new information on the impact of physical activity for cognitive impairment in breast cancer survivors. Findings from this study will inform guidelines for physical activity to improve the lives of millions of breast cancer survivors.
认知困难在乳腺癌幸存者中极为常见，会严重影响生活质量、日常功能和重返工作的能力。一种有前途的干预措施是增加身体活动，因为它在改善非癌症人群的认知方面非常有效。很少有针对认知结果的身体活动干预试验包括癌症幸存者。该项目基于我们之前的工作，表明增加身体活动可以提高乳腺癌幸存者的客观测量处理速度和自我报告认知。
I Can！研究将检查 250 名接受治疗后的乳腺癌幸存者（I-III 期，<5 年治疗后）的认知困难报告中，身体活动干预是否能改善认知。这是一项为期 6 个月的 2 臂随机对照试验，比较身体活动干预组（运动组）与健康与保健对照组（健康与保健组），以检查认知（在 3 个月和 6 个月时）和 12 个月时效果的维持情况。主要目的是研究运动对客观测量的处理速度和自我报告认知的影响。次要目的是维持认知变化，研究候选生物学机制和心理调节因素。
I Can！研究将为科学、公共卫生和生存干预文献做出贡献，提供关于身体活动对乳腺癌幸存者认知障碍影响的新信息。这项研究的结果将为改善数百万乳腺癌幸存者生活的身体活动指南提供信息。
