Hartman Sheri J, Natarajan Loki, Palmer Barton W, Parker Barbara, Patterson Ruth E, Sears Dorothy D
Department of Family Medicine and Public Health, UC San Diego, La Jolla, CA, USA; UC San Diego Moores Cancer Center, UC San Diego, La Jolla, CA, USA.
Department of Family Medicine and Public Health, UC San Diego, La Jolla, CA, USA; UC San Diego Moores Cancer Center, UC San Diego, La Jolla, CA, USA.
Contemp Clin Trials. 2015 Nov;45(Pt B):371-376. doi: 10.1016/j.cct.2015.09.021. Epub 2015 Sep 30.
Many breast cancer survivors experience problems with cognitive functioning that can persist years after treatment. Increasing physical activity has been shown to improve cognitive functioning in healthy and cognitively impaired adults, but has not yet been tested in cancer survivors. The primary aim of this randomized controlled trial is to examine the effects of a 3-month physical activity intervention compared to a waitlist Control arm on neuropsychological outcomes and subjective cognitive concerns in breast cancer survivors.
Eighty sedentary breast cancer survivors, self-reporting difficulties with cognition, will be randomized into an Exercise arm or Control arm. The Exercise arm includes an activity tracker (i.e., a Fitbit), phone calls, plus tailored and non-tailored email content. The Control arm will receive emails on women's health topics on the same schedule as the Exercise arm. Assessments conducted at baseline and 3 months include: neuropsychological testing, cognitive concerns and other aspects of quality of life, and 7 days of a hip-worn accelerometer. Participants will also provide fasting blood draws to assess brain-derived neurotropic factor, Insulin-like growth factor 1, insulin resistance, and C-reactive protein. Primary and secondary outcomes are changes in neuropsychological testing and cognitive concerns. Biomarkers will be examined to further understand the underlying relationship between physical activity and cognition.
The Memory & Motion study is designed to test whether increasing physical activity can improve cognitive functioning in breast cancer survivors. Results from this study could be used to guide development of interventions to improve cognitive functioning in breast cancer survivors.
许多乳腺癌幸存者存在认知功能问题，这些问题在治疗后可能会持续数年。已有研究表明，增加身体活动可改善健康及认知受损成年人的认知功能，但尚未在癌症幸存者中进行测试。这项随机对照试验的主要目的是，比较为期3个月的身体活动干预与等待名单对照组对乳腺癌幸存者神经心理学结果和主观认知问题的影响。
80名久坐不动且自我报告有认知困难的乳腺癌幸存者将被随机分为运动组或对照组。运动组包括一个活动追踪器（即Fitbit）、电话，以及量身定制和非量身定制的电子邮件内容。对照组将按照与运动组相同的时间表接收关于女性健康主题的电子邮件。在基线和3个月时进行的评估包括：神经心理学测试、认知问题及生活质量的其他方面，以及佩戴在髋部的加速度计记录的7天活动数据。参与者还将提供空腹血样，以评估脑源性神经营养因子、胰岛素样生长因子1、胰岛素抵抗和C反应蛋白。主要和次要结果是神经心理学测试和认知问题的变化。将对生物标志物进行检测，以进一步了解身体活动与认知之间的潜在关系。
“记忆与运动”研究旨在测试增加身体活动是否能改善乳腺癌幸存者的认知功能。这项研究的结果可用于指导开发改善乳腺癌幸存者认知功能的干预措施。
