Yadav Shailly, Haque Nizamie S, Das Basudeb, Das Jnanamay, Tikka Sai Krishna
Department of Psychiatry, ESIC Model Hospital, Gurugram, Haryana, India.
Former Director, Central Institute of Psychiatry, Kanke, Ranchi, 834006, India.
Asian J Psychiatr. 2021 Mar;57:102550. doi: 10.1016/j.ajp.2021.102550. Epub 2021 Jan 9.
Electrophysiological abnormalities, especially in the gamma frequency range, have been well documented in schizophrenia. This study was aimed to investigate the gamma spectral power of the brain in patients with first episode psychosis, using high-resolution electroencephalography.
Twenty-nine neuroleptic naïve/free male patients with non-affective psychosis as per ICD 10 DCR clinical criteria were compared with thirty age, sex, education and handedness matched healthy individuals as controls. All participants underwent 192-channel resting electroencephalography (EEG) recording. Gamma spectral power was calculated for low (31-50 Hz) and high-gamma (51-70 and 71-100 Hz) bands and compared between two groups using MANOVA and supplementary one-way ANOVA. Pearson correlation and linear regression analyses were conducted between spectral power parameters and various clinical variables.
The gamma spectral power in 31-50 Hz and 51-70 Hz frequency bands was found to be significantly higher in patients in most brain regions. Duration of illness predicted the gamma spectral power in both right and left frontal regions of the brain in the frequency range 31-50 Hz and 71-100 Hz, as well as in the right temporal region in 71-100 Hz range, where it was negatively correlated.
Patients with first episode psychosis have increased gamma spectral power, which might be indirectly related to the duration of illness.
精神分裂症患者存在电生理异常，尤其是在γ频段，这已得到充分证实。本研究旨在使用高分辨率脑电图研究首发精神病患者大脑的γ频谱功率。
根据ICD - 10 DCR临床标准，将29名未使用过抗精神病药物/未服用过抗精神病药物的非情感性精神病男性患者与30名年龄、性别、教育程度和利手相匹配的健康个体作为对照进行比较。所有参与者均接受192导静息脑电图（EEG）记录。计算低γ频段（31 - 50 Hz）和高γ频段（51 - 70 Hz和71 - 100 Hz）的γ频谱功率，并使用多变量方差分析（MANOVA）和补充单因素方差分析在两组之间进行比较。对频谱功率参数与各种临床变量进行Pearson相关分析和线性回归分析。
发现在大多数脑区，患者在31 - 50 Hz和51 - 70 Hz频段的γ频谱功率显著更高。病程预测了大脑左右额叶在31 - 50 Hz和71 - 100 Hz频率范围内以及右侧颞叶在71 - 100 Hz频率范围内的γ频谱功率，且呈负相关。
首发精神病患者的γ频谱功率增加，这可能与病程间接相关。
