Chair of Microwave Engineering, Christian-Albrechts-Universität zu Kiel, 24143 Kiel, Germany.
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States of America.
J Neural Eng. 2021 Mar 2;18(2). doi: 10.1088/1741-2552/abe099.
The aim of the present study was to investigate the accuracy of localization and rotational orientation detection of a directional deep brain stimulation (DBS) electrode using a state-of-the-art magnetoencephalography (MEG) scanner.A directional DBS electrode along with its stimulator was integrated into a head phantom and placed inside the MEG sensor array. The electrode was comprised of six directional and two omnidirectional contacts. Measurements were performed while stimulating with different contacts and parameters in the phantom. Finite element modeling and fitting approach were used to compute electrode position and orientation.The electrode was localized with a mean accuracy of 2.2 mm while orientation was determined with a mean accuracy of 11. The limitation in detection accuracy was due to the lower measurement precision of the MEG system. Considering an ideal measurement condition, these values represent the lower bound of accuracy that can be achieved in patients.However, a future magnetic measuring system with higher precision will potentially detect location and orientation of a DBS electrode with an even greater accuracy.
本研究旨在探讨使用最先进的脑磁图（MEG）扫描仪对定向深部脑刺激（DBS）电极的定位和旋转方向检测的准确性。将定向 DBS 电极及其刺激器集成到头部体模中，并放置在 MEG 传感器阵列内。该电极由六个定向和两个全向接触组成。在体模中对不同的接触和参数进行刺激时进行了测量。使用有限元建模和拟合方法来计算电极的位置和方向。电极的定位精度平均为 2.2 毫米，而方向的确定精度平均为 11。检测精度的限制是由于 MEG 系统的测量精度较低。考虑到理想的测量条件，这些值代表在患者中可以实现的精度下限。然而，具有更高精度的未来磁测量系统将有可能以更高的精度检测 DBS 电极的位置和方向。
