Dembek Till A, Hellerbach Alexandra, Jergas Hannah, Eichner Markus, Wirths Jochen, Dafsari Haidar Salimi, Barbe Michael T, Hunsche Stefan, Visser-Vandewalle Veerle, Treuer Harald
Department of Neurology, Faculty of Medicine, University of Cologne, D-50937 Cologne, Germany.
Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine, University of Cologne, D-50937 Cologne, Germany.
Brain Sci. 2021 Oct 31;11(11):1450. doi: 10.3390/brainsci11111450.
Directional deep brain stimulation (DBS) leads are now widely used, but the orientation of directional leads needs to be taken into account when relating DBS to neuroanatomy. Methods that can reliably and unambiguously determine the orientation of directional DBS leads are needed. In this study, we provide an enhanced algorithm that determines the orientation of directional DBS leads from postoperative CT scans. To resolve the ambiguity of symmetric CT artifacts, which in the past, limited the orientation detection to two possible solutions, we retrospectively evaluated four different methods in 150 Cartesia™ directional leads, for which the true solution was known from additional X-ray images. The method based on shifts of the center of mass (COM) of the directional marker compared to its expected geometric center correctly resolved the ambiguity in 100% of cases. In conclusion, the DiODe v2 algorithm provides an open-source, fully automated solution for determining the orientation of directional DBS leads.
定向性脑深部电刺激（DBS）电极目前已被广泛应用，但在将DBS与神经解剖结构联系起来时，需要考虑定向电极的方向。因此，需要能够可靠且明确地确定定向DBS电极方向的方法。在本研究中，我们提供了一种改进算法，可根据术后CT扫描确定定向DBS电极的方向。为了解决对称CT伪影的模糊性（过去，这种模糊性将方向检测限制为两种可能的解决方案），我们回顾性评估了150根Cartesia™定向电极中的四种不同方法，通过额外的X射线图像可知其真实解决方案。基于定向标记物质心（COM）与其预期几何中心的偏移量的方法在100%的病例中正确解决了模糊性。总之，DiODe v2算法为确定定向DBS电极的方向提供了一种开源、全自动的解决方案。
