采用24小时食管pH监测法对有婴儿猝死综合征风险的婴儿进行胃酸胃食管反流的探究：一项50例病例的研究。

Exploration of acid gastroesophageal reflux by 24-h pH metry in infants at risk of sudden infant death syndrome: a study of 50 cases.

作者信息

Baccino E, Le Goff D, Lancien G, Le Guillou M, Alix D, Mottier D

机构信息

Service de Médecine Interne, C.H.R. Morvan, Brest, France.

出版信息

Forensic Sci Int. 1988 Feb;36(3-4):255-60. doi: 10.1016/0379-0738(88)90152-1.

DOI:10.1016/0379-0738(88)90152-1

PMID:3350450

Abstract

This study focused on the frequency of pathological acid gastroesophageal reflux (AGER) on 50 children considered to be at risk for sudden infant death syndrome: that is to say, 30 near misses and 20 subsequent siblings. Four parameters were studied in a 24-h pH metry: (1) The percentage of time spent at pH less than 4. (2) The length of the longest reflux. (3) The number of refluxes greater than 5 min/h. (4) Esophageal clearance. In comparison to a control group of 46 normal children, we noted a rate of 20% of AGER on the near misses and 31% on children whose siblings had died from sudden infant death syndrome. The pH level of these two groups was significantly more often less than 4, compared to the normal children. The role of AGER in sudden infant death syndrome will, therefore, be discussed.

摘要

本研究聚焦于50名被认为有婴儿猝死综合征风险的儿童的病理性胃酸胃食管反流（AGER）频率，即30名接近死亡的婴儿和20名随后出生的兄弟姐妹。通过24小时pH值监测研究了四个参数：（1）pH值小于4的时间百分比。（2）最长反流的时长。（3）每小时反流超过5分钟的次数。（4）食管清除率。与46名正常儿童的对照组相比，我们注意到接近死亡的婴儿中AGER发生率为20%，其兄弟姐妹死于婴儿猝死综合征的儿童中该发生率为31%。与正常儿童相比，这两组的pH值水平明显更常低于4。因此，将讨论AGER在婴儿猝死综合征中的作用。