Instituto Universitario de Biotecnología y Biomedicina (BIOTECMED), Department of Genetics, Universitat de València, Burjassot, Spain.
Instituto Universitario de Biotecnología y Biomedicina (BIOTECMED), Department of Genetics, Universitat de València, Burjassot, Spain
Microbiol Mol Biol Rev. 2021 Jan 27;85(1). doi: 10.1128/MMBR.00007-20. Print 2021 Feb 17.
Extensive use of chemical insecticides adversely affects both environment and human health. One of the most popular biological pest control alternatives is bioinsecticides based on This entomopathogenic bacterium produces different protein types which are toxic to several insect, mite, and nematode species. Currently, insecticidal proteins belonging to the Cry and Vip3 groups are widely used to control insect pests both in formulated sprays and in transgenic crops. However, the benefits of -based products are threatened by insect resistance evolution. Numerous studies have highlighted that mutations in genes coding for surrogate receptors are responsible for conferring resistance to Nevertheless, other mechanisms may also contribute to the reduction of the effectiveness of -based products for managing insect pests and even to the acquisition of resistance. Here, we review the relevant literature reporting how invertebrates (mainly insects and ) respond to exposure to as either whole bacteria, spores, and/or its pesticidal proteins.
大量使用化学杀虫剂会对环境和人类健康造成不良影响。其中一种最受欢迎的生物防治方法是基于该昆虫病原细菌的生物杀虫剂，它能产生不同类型的蛋白，对多种昆虫、螨类和线虫具有毒性。目前，属于 Cry 和 Vip3 组的杀虫蛋白被广泛用于配制喷雾剂和转基作物中防治虫害。然而，基于的产品的优势受到昆虫抗药性进化的威胁。许多研究表明，编码替代受体的基因发生突变是导致对该细菌产生抗性的原因。然而，其他机制也可能导致基于的产品在防治虫害方面的效果降低，甚至导致抗性的产生。在这里，我们回顾了相关文献，报告了无脊椎动物（主要是昆虫和线虫）如何对整个细菌、孢子和/或其杀虫蛋白的暴露做出反应。
