Center for Protein and Cell-Based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518055, Shenzhen, People's Republic of China.
Guangdong Immune Cell Therapy Engineering And Technology Research Center (No. 2580 [2018]), Shezhen, People's Republic of China.
Cell Death Dis. 2021 Jan 27;12(1):129. doi: 10.1038/s41419-021-03428-x.
CAR-T transfer, recently well-developed immunotherapy, has offered substantial benefit to more and more patients with advanced cancers. However, along with growing experience in the clinical application comes the increasing awareness of the potentially fatal adverse effects, most notably cytokine release syndrome (CRS) and neurotoxicity. Understanding the mechanisms underlying these toxicities can help to improve therapeutic outcomes. Recent findings highlight the importance of monocyte/macrophage in CAR-T-related toxicities (CARTOX) and shed light on a novel mechanism mediated by damage-associated molecular patterns (DAMPs) released from pyroptotic cells. Therefore, this review summarizes these findings and provides practical guidance to the management of CARTOX.
嵌合抗原受体 T 细胞（CAR-T）疗法是一种新兴的免疫疗法，为越来越多的晚期癌症患者带来了显著的获益。然而，随着临床应用经验的不断增加，人们越来越意识到其潜在的致命不良反应，尤其是细胞因子释放综合征（CRS）和神经毒性。了解这些毒性的发生机制有助于改善治疗效果。最近的研究结果强调了单核细胞/巨噬细胞在 CAR-T 相关毒性（CARTOX）中的重要性，并揭示了一种由细胞焦亡释放的损伤相关分子模式（DAMPs）介导的新机制。因此，本综述总结了这些发现，并为 CARTOX 的管理提供了实用的指导。
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