Beniwal Shreya Singh, Calderón Daniela Castro, Baweja Tanish, Yadav Sweta, Vania Kareena, Priyadarshi Ashka, Ijantkar Saakshi, Kotaich Jana
Lady Hardinge Medical College, Connaught Place, New Delhi, India.
Universidad Peruana De Ciencias Aplicadas (UPC), Lima, Perú.
Ann Med Surg (Lond). 2025 May 20;87(7):4229-4236. doi: 10.1097/MS9.0000000000003412. eCollection 2025 Jul.
Chronic inflammation is the key pathophysiological link between psychological disorders and cardio-oncology, two seemingly separate clinical domains with increasingly acknowledged interdependencies. The inflammatory cascade not only plays a role in the etiology and development of several psychological disorders but is also a common biological substrate for cardiovascular difficulties in cancer patients (cardio-oncology). Despite mounting evidence of this tripartite link, clinical practice still uses fragmented integrated approaches to treating these interrelated illnesses. The purpose of this review is to compile the most recent data regarding the inflammatory pathways that are common to psychological illnesses, oncological processes, and cardiovascular side effects of cancer treatment. We examine how psychological discomfort in cancer patients worsens cardiovascular outcomes and how cardiovascular problems affect psychological well-being oppositely. Additionally, we assess new inflammatory biomarkers that may be useful for both diagnosis and prognosis in these disorders. This review offers a thorough framework for clinicians and researchers to address the intricate relationships between cancer treatment, psychological functioning, and cardiovascular health. It does so by looking at the most recent developments in anti-inflammatory interventions, pain management techniques, and integrated therapeutic approaches. Our goal is to draw attention to potential targeted therapies that use inflammatory pathway regulation to address several facets of this clinical triad at once.
慢性炎症是心理障碍与心脏肿瘤学之间关键的病理生理联系，这两个看似独立的临床领域，其相互依存关系越来越受到认可。炎症级联反应不仅在几种心理障碍的病因和发展中起作用，也是癌症患者心血管问题（心脏肿瘤学）的常见生物学基础。尽管有越来越多的证据表明存在这种三方联系，但临床实践仍采用零散的综合方法来治疗这些相互关联的疾病。本综述的目的是汇编有关心理疾病、肿瘤过程和癌症治疗的心血管副作用中常见的炎症途径的最新数据。我们研究癌症患者的心理不适如何恶化心血管结局，以及心血管问题如何相反地影响心理健康。此外，我们评估可能对这些疾病的诊断和预后都有用的新炎症生物标志物。本综述为临床医生和研究人员提供了一个全面的框架，以解决癌症治疗、心理功能和心血管健康之间的复杂关系。通过审视抗炎干预、疼痛管理技术和综合治疗方法的最新进展来实现这一目标。我们的目标是提请关注潜在的靶向治疗，这些治疗利用炎症途径调节来同时解决这个临床三联征的多个方面。
