Rajendran Ramya Lakshmi, Jogalekar Manasi Pandurang, Gangadaran Prakash, Ahn Byeong-Cheol
Department of Nuclear Medicine, Kyungpook National University, Daegu 41944, South Korea.
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
World J Stem Cells. 2020 Dec 26;12(12):1492-1510. doi: 10.4252/wjsc.v12.i12.1492.
Mounting evidence has emphasized the potential of cell therapies in treating various diseases by restoring damaged tissues or replacing defective cells in the body. Cell therapies have become a strong therapeutic modality by applying noninvasive molecular imaging for examining complex cellular processes, understanding pathophysiological mechanisms of diseases, and evaluating the kinetics/dynamics of cell therapies. In particular, mesenchymal stem cells (MSCs) have shown promise in recent years as drug carriers for cancer treatment. They can also be labeled with different probes and tracked to assess the effect of administered cells, and to optimize therapy. The exact role of MSCs in oncologic diseases is not clear as MSCs have been shown to be involved in tumor progression and inhibition, and the exact interactions between MSCs and specific cancer microenvironments are not clear. In this review, a multitude of labeling approaches, imaging modalities, and the merits/demerits of each strategy are outlined. In addition, specific examples of the use of MSCs and imaging in cancer therapy are provided. Finally, present limitations and future outlooks in terms of the translation of different imaging approaches in clinics are discussed.
越来越多的证据强调了细胞疗法通过修复受损组织或替代体内有缺陷的细胞来治疗各种疾病的潜力。通过应用非侵入性分子成像来检查复杂的细胞过程、理解疾病的病理生理机制以及评估细胞疗法的动力学/动态变化，细胞疗法已成为一种强大的治疗方式。特别是，间充质干细胞（MSCs）近年来作为癌症治疗的药物载体显示出了前景。它们还可以用不同的探针进行标记并追踪，以评估所施用细胞的效果，并优化治疗。由于MSCs已被证明参与肿瘤进展和抑制，且MSCs与特定癌症微环境之间的确切相互作用尚不清楚，因此MSCs在肿瘤疾病中的确切作用尚不清楚。在这篇综述中，概述了多种标记方法、成像方式以及每种策略的优缺点。此外，还提供了MSCs及其成像在癌症治疗中应用的具体例子。最后，讨论了不同成像方法在临床转化方面目前的局限性和未来展望。
