Egurrola Greciel E, Mazabel Angela P, García Johnbrynner
Belcorp Research and Development, Tocancipá 251017, Colombia.
J Anal Methods Chem. 2021 Jan 6;2021:6661744. doi: 10.1155/2021/6661744. eCollection 2021.
Most of the pharmaceutical and cosmetic products used for the treatment of dandruff have zinc pyrithione as an active ingredient; therefore; quantifying this component becomes necessary. The purpose of this study was the validation of two simple and fast methodologies in the quantification of zinc pyrithione for shampoo quality control to guarantee consumer safety. The first method comprised a manual complexometric titration, and the second comprised a potentiometric titration performed with an automatic titrator, obtaining sensitivity values of 0.0534% and 0.0038%, respectively, precision expressed in RSD% values below than 1%, and accuracy in recovery percentage greater than 99%. Additionally, both methods were robust when subjected to significant changes in working conditions (temperature and pH) and were selective even in the presence of interferences and degradation products. Finally, the methodologies were adequate to ensure the quality of shampoo to ensure the safety of consumers.
大多数用于治疗头皮屑的药品和化妆品都以吡啶硫酮锌作为活性成分；因此，对该成分进行定量分析很有必要。本研究的目的是验证两种简单快速的方法，用于定量分析吡啶硫酮锌以进行洗发水质量控制，从而保障消费者安全。第一种方法是手动络合滴定法，第二种方法是使用自动滴定仪进行电位滴定法，分别获得的灵敏度值为0.0534%和0.0038%，以相对标准偏差（RSD%）表示的精密度低于1%，回收率表示的准确度大于99%。此外，当工作条件（温度和pH值）发生显著变化时，这两种方法都很稳健，即使存在干扰物和降解产物时也具有选择性。最后，这些方法足以确保洗发水的质量，从而保障消费者的安全。
