Increased Circulating of CD54CD181 Neutrophils in Myelodysplastic Syndrome.

Myelodysplastic syndromes (MDSs) are a group of heterogeneous hematopoietic stem/progenitor cells clonal diseases, characteristic features with myeloid dysplasia, leading to abnormality of neutrophils. Recent studied have showed that neutrophils act not only as professional killers, but also as regulators of innate and adaptive immune in infection and inflammatory condition. The CD54CD181 neutrophils are a kind of reverse-transmigrated neutrophils characterized proinflammatory phenotype. We investigated the frequency and functional properties of circulating CD54CD181 neutrophils in patients with untreated MDS. Frequency of CD54CD181 neutrophils was significantly increased in MDS patients and related to the severity of the disease. Furthermore, CD54CD181 neutrophils suppressed CD8+ T cells functions . CD54CD181 neutrophils lead to upregulation of PD1 on CD8+ T cells. Higher CD54CD181 neutrophils were related to poor prognosis and more infections. The frequency of CD54CD181 neutrophils decreased in high risk MDS patients who had response after treatment with decitabine. Overall, we identified CD54CD181 neutrophils expanded in MDS. The exact mechanisms of increased CD54CD181 neutrophils and its effect on immune function remain to be elucidated.