Yang Liyan, Li Hongzhao, Liu Yumei, Xie Xinyan, Zhang Huiqin, Niu Haiyue, Shao Zonghong, Xing Limin, Wang Huaquan
Department of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Front Oncol. 2021 Jan 11;10:585216. doi: 10.3389/fonc.2020.585216. eCollection 2020.
Myelodysplastic syndromes (MDSs) are a group of heterogeneous hematopoietic stem/progenitor cells clonal diseases, characteristic features with myeloid dysplasia, leading to abnormality of neutrophils. Recent studied have showed that neutrophils act not only as professional killers, but also as regulators of innate and adaptive immune in infection and inflammatory condition. The CD54CD181 neutrophils are a kind of reverse-transmigrated neutrophils characterized proinflammatory phenotype. We investigated the frequency and functional properties of circulating CD54CD181 neutrophils in patients with untreated MDS. Frequency of CD54CD181 neutrophils was significantly increased in MDS patients and related to the severity of the disease. Furthermore, CD54CD181 neutrophils suppressed CD8+ T cells functions . CD54CD181 neutrophils lead to upregulation of PD1 on CD8+ T cells. Higher CD54CD181 neutrophils were related to poor prognosis and more infections. The frequency of CD54CD181 neutrophils decreased in high risk MDS patients who had response after treatment with decitabine. Overall, we identified CD54CD181 neutrophils expanded in MDS. The exact mechanisms of increased CD54CD181 neutrophils and its effect on immune function remain to be elucidated.
骨髓增生异常综合征（MDSs）是一组异质性造血干/祖细胞克隆性疾病，具有骨髓发育异常的特征，可导致中性粒细胞异常。最近的研究表明，中性粒细胞不仅作为专业杀手，而且在感染和炎症状态下作为先天性和适应性免疫的调节因子。CD54CD181中性粒细胞是一种具有促炎表型特征的反向迁移中性粒细胞。我们研究了未经治疗的MDS患者循环CD54CD181中性粒细胞的频率和功能特性。MDS患者中CD54CD181中性粒细胞的频率显著增加，且与疾病严重程度相关。此外，CD54CD181中性粒细胞抑制CD8+T细胞功能。CD54CD181中性粒细胞导致CD8+T细胞上PD1上调。较高的CD54CD181中性粒细胞与预后不良和更多感染相关。接受地西他滨治疗后有反应的高危MDS患者中CD54CD181中性粒细胞频率降低。总体而言,我们确定了MDS中CD54CD181中性粒细胞增多。CD54CD181中性粒细胞增加的确切机制及其对免疫功能的影响仍有待阐明。
