Department of Urology, Guizhou Provincial People's Hospital, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province 550002, China.
Department of Urology, The Second People's Hospital of Neijiang, Neijiang, Sichuan Province 641000, China.
Biomed Res Int. 2021 Jan 9;2021:4140767. doi: 10.1155/2021/4140767. eCollection 2021.
There is increasing evidence that dietary intake of sugars may be a risk factor for prostate cancer (PCa) and elevate the concentration of serum prostate-specific antigen (PSA). However, there is limited evidence of the correlation between total dietary intake of sugars and serum PSA concentrations for adult American males. Herein, we evaluated the association between total dietary intake of sugars and serum PSA concentrations in men without a malignant tumor diagnosis in the United States (US) National Health and Nutrition Examination Survey (NHANES) database. . In this secondary data analysis, a total of 6,403 men aged ≥40 years and without malignant tumor history were included from 2003 to 2010. The independent variable of this study was the total dietary intake of sugars, and the dependent variable was serum PSA concentrations. Covariates included dietary, comorbidity, physical examination, and demographic data.
The average age of participants included in this study was 58.1 years (±13.6). After adjusting for the dietary, comorbidity, physical examination, and demographic data, we observed that a dietary intake increase of one gram of total dietary intake of sugars was associated with an increase of serum PSA concentrations by 0.003 ng/mL (after log2 transformed, 95% CI: 0.001 to 0.005) with a value for trend less than 0.05. Sensitivity analysis using the generalized additive model (GAM) supported the linear association between total dietary intake of sugars and serum PSA concentrations.
The total dietary intake of sugars is independently and positively associated with serum PSA concentrations in adult American males who are without a personal history of malignant tumors.
越来越多的证据表明，糖的饮食摄入可能是前列腺癌（PCa）的一个风险因素，并会提高血清前列腺特异性抗原（PSA）的浓度。然而，对于美国成年男性，总糖饮食摄入量与血清 PSA 浓度之间的相关性证据有限。在此，我们在美国国家健康和营养调查（NHANES）数据库中评估了男性中总糖饮食摄入量与血清 PSA 浓度之间的关联，这些男性没有恶性肿瘤的诊断。
在这项二次数据分析中，我们纳入了 2003 年至 2010 年期间年龄≥40 岁且无恶性肿瘤史的 6403 名男性。本研究的自变量为总糖饮食摄入量，因变量为血清 PSA 浓度。协变量包括饮食、合并症、体检和人口统计学数据。
本研究中纳入的参与者的平均年龄为 58.1 岁（±13.6）。在调整饮食、合并症、体检和人口统计学数据后，我们观察到总糖饮食摄入量增加 1 克与血清 PSA 浓度增加 0.003ng/ml（经对数 2 转换后，95%CI：0.001 至 0.005）相关，趋势检验的 值小于 0.05。使用广义加性模型（GAM）的敏感性分析支持总糖饮食摄入量与血清 PSA 浓度之间的线性关联。
在没有恶性肿瘤个人史的美国成年男性中，总糖饮食摄入量与血清 PSA 浓度独立且呈正相关。
