UCL School of Pharmacy, London, WC1, UK.
Drug Deliv Transl Res. 2021 Apr;11(2):334-340. doi: 10.1007/s13346-020-00877-3. Epub 2021 Jan 28.
This account comprises personal reflections on the field of nanosystems primarily designed for the delivery of biologically active agents. It emphasises the colloidal nature of nanoparticles obeying the same physical laws that dictate the behaviour of disperse systems. Research reveals not only intrinsic complexities but a variety of possible trajectories in vivo and ex vivo, issues of stability, interactions and behaviour in a range of often constrained environments. Such are the variations in the chemical and physical nature of the nanosystems and the active agents they carry, their putative "targets" and the many biological systems and models in which they are employed, it is not possible to generalise. Stochastic events may exclude precise prediction or extrapolation of outcomes, but embracing and studying complexity lead to new insights, often aided by consideration of analogies in cognate areas. This is part of the process of illumination. Unexpected results provide the true essence and excitement of scientific endeavour. Simplification is perhaps its antithesis.
这篇文章主要是对纳米系统领域的个人反思，该领域主要设计用于生物活性物质的传递。它强调了纳米颗粒的胶体性质，这些颗粒遵循着同样的物理定律，这些物理定律决定了分散系统的行为。研究不仅揭示了内在的复杂性，还揭示了体内和体外的各种可能轨迹、稳定性问题、在一系列经常受限的环境中的相互作用和行为。纳米系统及其携带的生物活性物质、它们的假定“靶点”以及它们所使用的许多生物系统和模型，在化学和物理性质上存在着如此多的变化，以至于不可能进行概括。随机事件可能会排除对结果的精确预测或推断，但接受并研究复杂性会带来新的见解，通常通过考虑同源领域的类比来辅助。这是启示过程的一部分。意外的结果提供了科学努力的真正本质和兴奋。简化也许是它的对立面。
