Soloway A H, Wright J E, Subramanyam V, Gozzo J J
J Med Chem. 1977 Nov;20(11):1357-62. doi: 10.1021/jm00221a001.
The preparation of a series of water-soluble mustard haptens for chemoimmunotherapy of cancer is described. Preliminary screening data are given, indicating some activity against P388 lymphocytic leukemia for those compounds containing the most potent immunogenic functional groups.
本文描述了一系列用于癌症化学免疫治疗的水溶性芥子气半抗原的制备方法。给出了初步筛选数据,表明对于那些含有最强免疫原性功能基团的化合物,对P388淋巴细胞白血病具有一定活性。