Alonso G, Alonso R, Camarasa M J, Contreras A, García López M T, de las Heras F G, Herranz R, Sánchez-Pérez R M
Rev Esp Oncol. 1982;29(4):603-7.
A model to produce a new type of alkylating agents having anti-cancer activity is described. They consist of a halomethyl-azol group of the benzyl type as alkylating center, and a sugar moiety as a carrier fragment. Alkylating nucleosides were produced as halomethyl-pyrazole, -imidazole, 1.2.3-triazole, and 1.2.4-triazole derivatives following the model, and tested upon Ehrlich ascites cancer and P-388 lymphocytic leukemia.
描述了一种用于生产具有抗癌活性的新型烷基化剂的模型。它们由苄基型卤代甲基-唑基团作为烷基化中心和糖部分作为载体片段组成。按照该模型制备了作为卤代甲基-吡唑、-咪唑、1,2,3-三唑和1,2,4-三唑衍生物的烷基化核苷，并对艾氏腹水癌和P-388淋巴细胞白血病进行了测试。
