Xie Jiani, Zhao Maoru, Wang Chengyan, Yong Yuan, Gu Zhanjun, Zhao Yuliang
School of Food and Biological Engineering, Chengdu University, Chengdu, 610106, China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
Adv Healthc Mater. 2021 Mar;10(6):e2001615. doi: 10.1002/adhm.202001615. Epub 2021 Jan 27.
Radiation treatments often unfavorably damage neighboring healthy organs and cause a series of radiation sequelae, such as radiation-induced hematopoietic system diseases, radiation-induced gastrointestinal diseases, radiation-induced lung diseases, and radiation-induced skin diseases. Recently, emerging nanomaterials have exhibited good superiority for these radiation-induced disease treatments. Given this background, the rational design principle of nanomaterials, which helps to optimize the therapeutic efficiency, has been an increasing need. Consequently, it is of great significance to perform a systematic summarization of the advances in this field, which can trigger the development of new high-performance nanoradioprotectors with drug efficiency maximization. Herein, this review highlights the advances and perspectives in the rational design of nanomaterials for preventing and treating various common radiation-induced diseases. Furthermore, the sources, clinical symptoms, and pathogenesis/injury mechanisms of these radiation-induced diseases will also be introduced. Furthermore, current challenges and directions for future efforts in this field are also discussed.
放射治疗常常会对邻近的健康器官造成不利损害，并引发一系列放射后遗症，如辐射诱导的造血系统疾病、辐射诱导的胃肠道疾病、辐射诱导的肺部疾病以及辐射诱导的皮肤疾病。近年来，新兴的纳米材料在这些辐射诱导疾病的治疗中展现出了良好的优势。鉴于此背景，有助于优化治疗效果的纳米材料合理设计原则的需求日益增加。因此，对该领域的进展进行系统总结具有重要意义，这能够推动新型高效纳米辐射防护剂的开发，实现药物效率最大化。在此，本综述重点介绍了用于预防和治疗各种常见辐射诱导疾病的纳米材料合理设计方面的进展和前景。此外，还将介绍这些辐射诱导疾病的来源、临床症状以及发病机制/损伤机制。此外，还讨论了该领域当前面临的挑战以及未来的努力方向。
