Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.
Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Urologia. 2022 May;89(2):185-194. doi: 10.1177/0391560321990271. Epub 2021 Jan 28.
Renal involvement by Non-Hodgkin's lymphoma (NHL) is very rare, and involvement of the kidney as the primary site of NHL (PRNHL) is much more uncommon. Gold standard for the diagnosis of PRNHL is histology and imaging modalities although helpful are not specific. Nephrectomy has been mostly recommended for low grade lymphomas, and for high grade PRNHLs, chemotherapy without nephrectomy has been recommended as the treatment of choice. This tumor is aggressive with poor prognosis. This poor prognosis is partly because of delayed diagnosis and partly because of unnecessary surgeries, so it should be kept in mind, especially in bilateral renal tumors with unusual imaging characteristics, to take a tissue biopsy before nephrectomy. In this review, we will discuss all the detailed aspects of clinical, pathologic, and imaging characteristics of 83 cases of PRNHL reported in the last 20 years in the English literature so far. For this purpose, all the published cases of the primary non-Hodgkin's lymphoma of kidney were reviewed via a search in PubMed, Scopus, and Google Scholar, (1999-2019), using the keywords of "Primary renal lymphoma" and "Non-Hodgkin's lymphoma and kidney," "renal Non-Hodgkin's lymphoma," "renal lymphoma," and "lymphoma and kidney." There were 83 cases in the published English literature which were reviewed for this article. There was some missing information in some cases which has been recorded as "not reported."
肾脏非霍奇金淋巴瘤(NHL)很少见,而肾脏作为 NHL 的主要发病部位(PRNHL)更为罕见。PRNHL 的诊断金标准是组织学和影像学检查,但这些检查虽然有帮助,但并不具有特异性。对于低度恶性淋巴瘤,大多推荐行肾切除术,而对于高度恶性 PRNHL,推荐在不进行肾切除术的情况下进行化疗作为首选治疗方法。这种肿瘤具有侵袭性和不良预后。这种不良预后部分是由于诊断延迟,部分是由于不必要的手术,因此在考虑行肾切除术之前,对于双侧肾脏肿瘤且影像学特征不典型者,应牢记进行组织活检。在这篇综述中,我们将讨论过去 20 年中在英文文献中报道的 83 例 PRNHL 的所有详细临床、病理和影像学特征。为此,通过在 PubMed、Scopus 和 Google Scholar 上搜索“原发性肾淋巴瘤”和“非霍奇金淋巴瘤和肾脏”、“肾非霍奇金淋巴瘤”、“肾淋巴瘤”和“淋巴瘤和肾脏”等关键词,回顾了所有已发表的关于肾脏原发性非霍奇金淋巴瘤的病例。本文共回顾了 83 例已发表的英文文献中的病例。由于部分病例的信息缺失,我们将其记录为“未报道”。