Department of Medical Sciences and Public Health, Division Pathological Anatomy, Cagliari, Italy.
Eur Rev Med Pharmacol Sci. 2021 Jan;25(1):431-437. doi: 10.26355/eurrev_202101_24411.
Thymosin beta 4 (TB4) is the most abundant member of the beta-thymosin family in humans. The main physiological role of TB4 is the regulation of actin polymerization. TB4 is also involved in angiogenesis, cell survival, cell migration and fetal development. The aim of this study was to evaluate the activity of TB4 as a fetal growth promoter when administered during pregnancy.
Our protocols have been carried out in full conformity with the rules and guidelines expected for this kind of trial. 10 pregnant mice received the same injection regimen. Only 6 of these 10 are part of this experiment because they were pregnant. At 10:00 a.m. on day E14 and E17 of gestation mice were weighed and treated with an intraperitoneal injection of TB4 (Regene RX, Rockville, MD, USA; 6 mg/kg in PBS).
The mothers treated with TB4 for two days precisely E14 and E17, showed a higher cranio-caudal length when compared to control newborns. At histology, maternal TB4 treatment was associated with more advanced development of lungs, heart, kidney, cerebral cortex and notochord.
Our study shows that TB4 administration during gestation may act as a powerful fetal growth promoter, by accelerating the development of newborn organs and tissues.
胸腺素β 4（TB4）是人类β-胸腺素家族中含量最丰富的成员。TB4 的主要生理作用是调节肌动蛋白聚合。TB4 还参与血管生成、细胞存活、细胞迁移和胎儿发育。本研究旨在评估 TB4 作为妊娠期间胎儿生长促进剂的活性。
我们的方案完全符合此类试验预期的规则和指南。10 只怀孕的老鼠接受了相同的注射方案。由于它们处于怀孕状态，只有其中的 6 只被纳入了这项实验。在妊娠第 14 天和第 17 天的上午 10 点，对老鼠进行称重，并通过腹腔内注射 TB4（Regene RX，马里兰州罗克维尔；6mg/kg 在 PBS 中）进行治疗。
在妊娠第 14 天和第 17 天接受 TB4 治疗两天的母亲，与对照组的新生儿相比，头尾部长度更高。组织学检查显示，母体 TB4 治疗与肺、心脏、肾脏、大脑皮层和脊索的更高级发育有关。
我们的研究表明，妊娠期间给予 TB4 可能作为一种强大的胎儿生长促进剂，通过加速新生儿器官和组织的发育来发挥作用。
