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瑞德西韦作为一种广谱抗 COVID-19 病毒药物。

Remdesivir as a broad-spectrum antiviral drug against COVID-19.

机构信息

Zhejiang Sci-Tech University, Zhejiang, HangZhou, China.

出版信息

Eur Rev Med Pharmacol Sci. 2021 Jan;25(1):541-548. doi: 10.26355/eurrev_202101_24426.

DOI:10.26355/eurrev_202101_24426
PMID:33506946
Abstract

OBJECTIVE

List the clinical data of the role of remdesivir in COVID-19, and try to make an objective evaluation and analyze its feasibility.

MATERIALS AND METHODS

The keywords of "remdesivir", "COVID-19" and "SARS-CoV-2" were systematically searched in PubMed and Web of Science. After removing the repetitions, we summarize articles, letters, and comments on remdesivir in the treatment of COVID-19.

RESULTS

In this review, we summarize clinical case of using remdesivir in the treatment of COVID-19, analyzed the final treatment results, and judged whether the drug was effective for the treatment of COVID-19. Also, attention was paid to the side effects of the drug.

CONCLUSIONS

According to the clinical results, it was found that remdesivir was effective in the treatment of COVID-19. The drug has side effects, but the symptoms were mild and disappeared immediately after discontinuation of medication.

摘要

目的

列举瑞德西韦在 COVID-19 中的临床数据,并尝试进行客观评价,分析其可行性。

材料与方法

系统检索 PubMed 和 Web of Science 中“remdesivir”“COVID-19”和“SARS-CoV-2”的关键词,去除重复后,对瑞德西韦治疗 COVID-19 的相关文章、信件和评论进行总结。

结果

在本次综述中,我们总结了使用瑞德西韦治疗 COVID-19 的临床病例,分析了最终的治疗结果,判断该药物对 COVID-19 的治疗是否有效,同时也关注了药物的副作用。

结论

根据临床结果发现,瑞德西韦在治疗 COVID-19 方面是有效的。该药物有一定副作用,但症状较轻,停药后立即消失。

相似文献

1
Remdesivir as a broad-spectrum antiviral drug against COVID-19.瑞德西韦作为一种广谱抗 COVID-19 病毒药物。
Eur Rev Med Pharmacol Sci. 2021 Jan;25(1):541-548. doi: 10.26355/eurrev_202101_24426.
2
Should Remdesivir Be Used for the Treatment of Patients With COVID-19? Rapid, Living Practice Points From the American College of Physicians (Version 1).瑞德西韦是否应用于治疗 COVID-19 患者?美国医师学会的快速实践要点(第 1 版)。
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Remdesivir (Veklury) for COVID-19.用于治疗新冠肺炎的瑞德西韦(Veklury)
Med Lett Drugs Ther. 2020 Nov 30;62(1612):186-188.
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COVID-19 updates: Remdesivir (Veklury) in high-risk outpatients with COVID-19.2019冠状病毒病最新情况:瑞德西韦(Veklury)用于高危2019冠状病毒病门诊患者。
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Remdesivir for patients with COVID-19.瑞德西韦用于治疗新冠肺炎患者。
CMAJ. 2021 Jan 25;193(4):E125. doi: 10.1503/cmaj.202505. Epub 2021 Jan 6.
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Update Alert 2: Remdesivir for Adults With COVID-19.最新警报2:用于成人新冠肺炎患者的瑞德西韦。
Ann Intern Med. 2021 Dec;174(12):W114-W115. doi: 10.7326/L21-0600. Epub 2021 Oct 5.
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Efficacy and harms of remdesivir for the treatment of COVID-19: A systematic review and meta-analysis.瑞德西韦治疗 COVID-19 的疗效和危害:系统评价和荟萃分析。
PLoS One. 2020 Dec 10;15(12):e0243705. doi: 10.1371/journal.pone.0243705. eCollection 2020.
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Audio Interview: New Data on Remdesivir in Covid-19.音频访谈:瑞德西韦治疗新冠病毒病的新数据
N Engl J Med. 2020 May 28;382(22):e94. doi: 10.1056/NEJMe2019975.
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Antiviral treatment for COVID-19: the evidence supporting remdesivir.针对 COVID-19 的抗病毒治疗:瑞德西韦的证据支持。
Clin Med (Lond). 2020 Nov;20(6):e215-e217. doi: 10.7861/clinmed.2020-0524. Epub 2020 Aug 30.
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Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial.瑞德西韦对比标准治疗对 11 天内中症 COVID-19 患者临床状态的影响:一项随机临床试验。
JAMA. 2020 Sep 15;324(11):1048-1057. doi: 10.1001/jama.2020.16349.

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Potent Molecular Feature-based Neutralizing Monoclonal Antibodies as Promising Therapeutics Against SARS-CoV-2 Infection.基于强效分子特征的中和单克隆抗体有望成为抗SARS-CoV-2感染的治疗药物。
Front Mol Biosci. 2021 May 31;8:670815. doi: 10.3389/fmolb.2021.670815. eCollection 2021.
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Remdesivir, Renal Function and Short-Term Clinical Outcomes in Elderly COVID-19 Pneumonia Patients: A Single-Centre Study.瑞德西韦在老年 COVID-19 肺炎患者中的应用:一项单中心研究。
Clin Interv Aging. 2021 Jun 3;16:1037-1046. doi: 10.2147/CIA.S313028. eCollection 2021.