微肽在生物学中的作用。
The role of micropeptides in biology.
机构信息
Departamento de Cirurgia E Fisiologia, Faculdade de Medicina da Universidade Do Porto, UnIC, Porto, Portugal.
Department of Medical Sciences, iBiMED, University of Aveiro, Aveiro, Portugal.
出版信息
Cell Mol Life Sci. 2021 Apr;78(7):3285-3298. doi: 10.1007/s00018-020-03740-3. Epub 2021 Jan 28.
Abstract
Micropeptides are small polypeptides coded by small open-reading frames. Progress in computational biology and the analyses of large-scale transcriptomes and proteomes have revealed that mammalian genomes produce a large number of transcripts encoding micropeptides. Many of these have been previously annotated as long noncoding RNAs. The role of micropeptides in cellular homeostasis maintenance has been demonstrated. This review discusses different types of micropeptides as well as methods to identify them, such as computational approaches, ribosome profiling, and mass spectrometry.
摘要
微肽是由小开放阅读框编码的小多肽。计算生物学的进展以及大规模转录组和蛋白质组的分析表明，哺乳动物基因组产生大量编码微肽的转录本。其中许多以前被注释为长非编码 RNA。微肽在细胞内稳态维持中的作用已得到证实。本文讨论了不同类型的微肽以及识别它们的方法，如计算方法、核糖体图谱和质谱。
相似文献
1
The role of micropeptides in biology.
Cell Mol Life Sci. 2021 Apr;78(7):3285-3298. doi: 10.1007/s00018-020-03740-3. Epub 2021 Jan 28.
2
Micropeptides Identified from Human Genomes.
J Proteome Res. 2022 Apr 1;21(4):865-873. doi: 10.1021/acs.jproteome.1c00889. Epub 2022 Mar 7.
3
Micropeptides translated from putative long non-coding RNAs.
Acta Biochim Biophys Sin (Shanghai). 2022 Mar 25;54(3):292-300. doi: 10.3724/abbs.2022010.
4
Mining for missed sORF-encoded peptides.
Expert Rev Proteomics. 2019 Mar;16(3):257-266. doi: 10.1080/14789450.2019.1571919. Epub 2019 Feb 13.
5
Mining for Micropeptides.
Trends Cell Biol. 2017 Sep;27(9):685-696. doi: 10.1016/j.tcb.2017.04.006. Epub 2017 May 18.
6
When Long Noncoding Becomes Protein Coding.
Mol Cell Biol. 2020 Feb 27;40(6). doi: 10.1128/MCB.00528-19.
7
Global analysis of ribosome-associated noncoding RNAs unveils new modes of translational regulation.
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E10018-E10027. doi: 10.1073/pnas.1708433114. Epub 2017 Oct 30.
8
Translation and natural selection of micropeptides from long non-canonical RNAs.
Nat Commun. 2022 Oct 31;13(1):6515. doi: 10.1038/s41467-022-34094-y.
9
Combining in silico prediction and ribosome profiling in a genome-wide search for novel putatively coding sORFs.
BMC Genomics. 2013 Sep 23;14:648. doi: 10.1186/1471-2164-14-648.
10
[Progress on sORF-encoded micropeptides].
Yi Chuan. 2021 Aug 20;43(8):737-746. doi: 10.16288/j.yczz.21-167.
引用本文的文献
1
Tutorial: guidelines for the use of machine learning methods to mine genomes and proteomes for antibiotic discovery.
Nat Protoc. 2025 May 14. doi: 10.1038/s41596-025-01144-w.
2
Endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugs.
Front Pharmacol. 2025 Apr 8;16:1545575. doi: 10.3389/fphar.2025.1545575. eCollection 2025.
3
A micropeptide regulates seed desiccation.
Front Plant Sci. 2025 Mar 26;16:1550190. doi: 10.3389/fpls.2025.1550190. eCollection 2025.
4
Glutathiones' life in multi-cancers: especially their potential micropetides in liver hepatocellular carcinoma.
Discov Oncol. 2025 Feb 18;16(1):201. doi: 10.1007/s12672-025-01945-1.
5
HPV E6/E7-Induced Acetylation of a Peptide Encoded by a Long Non-Coding RNA Inhibits Ferroptosis to Promote the Malignancy of Cervical Cancer.
Adv Sci (Weinh). 2025 Mar;12(10):e2414018. doi: 10.1002/advs.202414018. Epub 2025 Jan 21.
6
Translational regulation of PKD1 by evolutionarily conserved upstream open reading frames.
RNA Biol. 2025 Dec;22(1):1-12. doi: 10.1080/15476286.2024.2448387. Epub 2025 Jan 5.
7
The small protein LINC01547-ORF inhibits colorectal cancer progression by regulating the CLDN18-FAK-AKT axis.
Am J Cancer Res. 2024 Nov 15;14(11):5504-5520. doi: 10.62347/PNKH7683. eCollection 2024.
8
Emerging role of endogenous peptides encoded by non-coding RNAs in cancer biology.
Noncoding RNA Res. 2024 Oct 28;10:231-241. doi: 10.1016/j.ncrna.2024.10.006. eCollection 2025 Feb.
9
Multi-Omic Approaches in Cancer-Related Micropeptide Identification.
Proteomes. 2024 Sep 13;12(3):26. doi: 10.3390/proteomes12030026.
10
A small protein encoded by PCBP1-AS1 is identified as a key regulator of influenza virus replication via enhancing autophagy.
PLoS Pathog. 2024 Aug 13;20(8):e1012461. doi: 10.1371/journal.ppat.1012461. eCollection 2024 Aug.
本文引用的文献
1
Identification and analysis of short open reading frames (sORFs) in the initially annotated noncoding RNA LINC00493 from human cells.
J Biochem. 2021 Apr 29;169(4):421-434. doi: 10.1093/jb/mvaa143.
2
A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation.
Sci Adv. 2020 May 20;6(21):eaaz2059. doi: 10.1126/sciadv.aaz2059. eCollection 2020 May.
3
Using AnABlast for intergenic sORF prediction in the Caenorhabditis elegans genome.
Bioinformatics. 2020 Dec 8;36(19):4827-4832. doi: 10.1093/bioinformatics/btaa608.
4
Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases.
Sci China Life Sci. 2020 Jul;63(7):953-985. doi: 10.1007/s11427-020-1702-x. Epub 2020 Apr 30.
5
Micropeptide MIAC Inhibits HNSCC Progression by Interacting with Aquaporin 2.
J Am Chem Soc. 2020 Apr 8;142(14):6708-6716. doi: 10.1021/jacs.0c00706. Epub 2020 Mar 24.
6
A Novel Micropeptide Encoded by Y-Linked LINC00278 Links Cigarette Smoking and AR Signaling in Male Esophageal Squamous Cell Carcinoma.
Cancer Res. 2020 Jul 1;80(13):2790-2803. doi: 10.1158/0008-5472.CAN-19-3440. Epub 2020 Mar 13.
7
LINC01420 RNA structure and influence on cell physiology.
BMC Genomics. 2019 May 8;20(Suppl 3):298. doi: 10.1186/s12864-019-5538-z.
8
A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome.
J Immunol. 2020 Jan 15;204(2):428-437. doi: 10.4049/jimmunol.1900791. Epub 2019 Dec 13.
9
Micropeptide CIP2A-BP encoded by LINC00665 inhibits triple-negative breast cancer progression.
EMBO J. 2020 Jan 2;39(1):e102190. doi: 10.15252/embj.2019102190. Epub 2019 Nov 22.
10
MiPepid: MicroPeptide identification tool using machine learning.
BMC Bioinformatics. 2019 Nov 8;20(1):559. doi: 10.1186/s12859-019-3033-9.
Zotero 插件