Horner K C, Guilhaume A, Cazals Y
Laboratoire d'Audiologie Expérimentale, INSERM Unité 229, Université Bordeaux II, Hôpital Pellegrin, France.
Hear Res. 1988 Jan;32(1):41-8. doi: 10.1016/0378-5955(88)90145-1.
Scanning electron microscopy was employed to investigate hair cell morphology at different stages in the development of experimentally induced hydrops in the guinea pig. A particular form of morpho-pathology, never before described, was identified as characteristic of hydropic cochleas. The pathology was characteristically identified as atrophy of the short and middle stereocilia on the outer hair cells while the inner hair cell stereocilia did not have such a pathology. The atrophy was restricted to the upper cochlear turns in remarkable correspondence with the low/middle frequency sensitivity loss and was detected only at the end of the period of fluctuating thresholds. These stereocilia perturbations appear therefore to be linked with the threshold fluctuations and represent the first evidence for a clear correlation between hair cell morphology and physiology in the experimental model of endolymphatic hydrops. Such a morphopathology might also be expected to occur in cochleas of Menière's patients but may have been overlooked in the past because of the discrete nature of the pathology.
采用扫描电子显微镜研究豚鼠实验性诱导积水不同发育阶段的毛细胞形态。一种以前从未描述过的特殊形态病理学形式被确定为积水性耳蜗的特征。这种病理学特征性地表现为外毛细胞上短和中静纤毛的萎缩，而内毛细胞静纤毛没有这种病理学改变。萎缩局限于耳蜗上转，与低频/中频听力损失显著相关，并且仅在阈值波动期结束时才被检测到。因此，这些静纤毛扰动似乎与阈值波动有关，并且代表了内淋巴积水实验模型中毛细胞形态与生理之间明确相关性的首个证据。这种形态病理学也可能预期发生在梅尼埃病患者的耳蜗中，但由于病理学的离散性质，过去可能被忽视了。
