有机光氧化还原催化促进羧酸的快速碳同位素交换。
Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis.
机构信息
Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Department of Biochemistry, Microbiology and Immunology and Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
出版信息
J Am Chem Soc. 2021 Feb 10;143(5):2200-2206. doi: 10.1021/jacs.0c12819. Epub 2021 Jan 28.
Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange of C(sp) acids with labeled CO. Substrates that are not compatible with transition-metal-catalyzed degradation-reconstruction approaches or prone to thermally induced reversible decarboxylation undergo isotopic incorporation at room temperature in short reaction times. The radiolabeling of drug molecules and precursors with [C]CO is demonstrated.
咔唑/氰基苯光催化剂促进 C(sp 3 )酸与标记的 CO 的直接同位素羧酸交换。与过渡金属催化的降解-重建方法不兼容或易于热诱导可逆脱羧的底物，在短反应时间内在室温下进行同位素掺入。用 [C]CO 对药物分子和前体进行放射性标记。
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