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基于非法药物使用戒除的客观指标的应急管理治疗的长期疗效:一项荟萃分析。

Long-term efficacy of contingency management treatment based on objective indicators of abstinence from illicit substance use up to 1 year following treatment: A meta-analysis.

机构信息

Department of Psychology.

Department of Psychiatry and Human Behavior.

出版信息

J Consult Clin Psychol. 2021 Jan;89(1):58-71. doi: 10.1037/ccp0000552.

DOI:10.1037/ccp0000552
PMID:33507776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8034391/
Abstract

OBJECTIVE

Contingency management (CM) is often criticized for limited long-term impact. This meta-analysis focused on objective indices of drug use (i.e., urine toxicology) to examine the effects of CM on illicit substance use up to 1 year following treatment.

METHOD

Analyses included randomized trials (k = 23) of CM for stimulant, opioid, or polysubstance use disorders that reported outcomes up to 1 year after the incentive delivery had ended. Using random effects models, odds ratios (OR) were calculated for the likelihood of abstinence. Metaregressions and subgroup analyses explored how parameters of CM treatment, namely escalation, frequency, immediacy, and magnitude of reinforcers, moderated outcomes.

RESULTS

The overall likelihood of abstinence at the long-term follow-up among participants who received CM versus a comparison treatment (nearly half of which were community-based comprehensive therapies or protocol-based specific therapies) was OR = 1.22, 95% confidence interval [1.01, 1.44], with low to moderate heterogeneity (² = 36.68). Among 18 moderators, longer length of active treatment was found to significantly improve long-term abstinence.

CONCLUSIONS

CM showed long-term benefit in reducing objective indices of drug use, above and beyond other active, evidence-based treatments (e.g., cognitive-behavioral therapy, 12-step facilitation) and community-based intensive outpatient treatment. These data suggest that policymakers and insurers should support and cover costs for CM, which is the focus of hundreds of studies demonstrating its short-term efficacy and, now, additional data supporting its long-term efficacy. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

摘要

目的

应急管理(CM)经常因长期效果有限而受到批评。本荟萃分析侧重于药物使用的客观指标(即尿液毒理学),以检查在激励措施结束后长达 1 年的时间内,CM 对非法物质使用的影响。

方法

分析包括针对兴奋剂、阿片类药物或多药物使用障碍的 CM 的随机试验(k = 23),这些试验报告了激励措施结束后长达 1 年的结果。使用随机效应模型,计算了 CM 治疗(即升级、频率、即时性和强化物的幅度)对戒断可能性的比值比(OR)。元回归和亚组分析探讨了 CM 治疗的参数,即升级、频率、即时性和强化物的幅度,如何调节结果。

结果

与接受对照治疗的参与者相比,在长期随访中,接受 CM 治疗的参与者保持戒断的总体可能性为 OR = 1.22,95%置信区间[1.01,1.44],异质性低至中度(²= 36.68)。在 18 个调节因素中,发现更长的治疗时间可显著提高长期戒断率。

结论

CM 在减少药物使用的客观指标方面显示出长期益处,优于其他积极的、基于证据的治疗方法(例如认知行为疗法、12 步促进法)和基于社区的强化门诊治疗。这些数据表明,政策制定者和保险公司应该支持和承担 CM 的费用,CM 是数百项研究证明其短期疗效的重点,现在还有更多数据支持其长期疗效。(PsycInfo 数据库记录(c)2021 APA,保留所有权利)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3df3/8034391/1c9b28da404d/nihms-1687070-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3df3/8034391/eb49adcbcf62/nihms-1687070-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3df3/8034391/1c9b28da404d/nihms-1687070-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3df3/8034391/eb49adcbcf62/nihms-1687070-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3df3/8034391/1c9b28da404d/nihms-1687070-f0002.jpg

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