Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, China.
J Palliat Med. 2021 Sep;24(9):1314-1320. doi: 10.1089/jpm.2020.0640. Epub 2021 Jan 27.
Integrated palliative care in oncology service has been widely implemented in Hong Kong since 2006. The study aimed to review its impact on end-of-life outcomes and overall survival (OS) of cancer patients, as well as its utilization of health care resources in the past 10 years. Cancer deaths of all 43 public hospitals of Hong Kong were screened. Randomly selected 2800 cancer deaths formed a representative cohort in all seven service clusters of Hospital Authority at four time points (2006, 2009, 2012, and 2015). Individual patient records were thoroughly reviewed. Propensity score-matched (PSM) analysis was employed to compare the survival of patients. Palliative care provision was associated with improved palliative care outcome, including more prescription of strong opioid, fewer cardiopulmonary resuscitations and intensive care unit admissions, and less futile chemotherapy usage in the end-of-life period (all < 0.001). In the PSM analysis, the median OS in patients with palliative service (5.10 months, 95% confidence interval [CI] 4.52-5.68 months) was significantly better than those without palliative service (1.96 months, 95% CI 1.66-2.27 months). Patients in the palliative care group had more specialist clinic visits ( < 0.001) and longer hospital stay ( < 0.001) in the last six months of life, although the duration of last admission stay at acute general ward was shortened ( < 0.001). Our results suggested palliative care has played a role in the remarkable improvement in end-of-life outcomes and OS. However, current palliative care model relied heavily on hospital resources. Future work is needed to strengthen community care and to build up quality monitoring systems.
自 2006 年以来,香港已广泛实施肿瘤学服务中的综合姑息治疗。本研究旨在回顾其对癌症患者临终结局和总生存期(OS)的影响,以及过去 10 年中对卫生保健资源的利用情况。筛选了香港所有 43 家公立医院的癌症死亡病例。随机选择的 2800 例癌症死亡病例在医院管理局的七个服务组中形成了具有代表性的队列,共分四个时间点(2006 年、2009 年、2012 年和 2015 年)。仔细审查了每个患者的记录。采用倾向评分匹配(PSM)分析比较患者的生存情况。姑息治疗的提供与改善姑息治疗结局相关,包括更强效阿片类药物的更多处方、心肺复苏和重症监护病房入院的减少,以及临终期无效化疗的使用减少(均<0.001)。在 PSM 分析中,姑息治疗组患者的中位 OS(5.10 个月,95%置信区间[CI]4.52-5.68 个月)明显优于无姑息治疗组(1.96 个月,95%CI1.66-2.27 个月)。姑息治疗组患者在生命的最后六个月中接受了更多的专科门诊就诊(<0.001)和更长的住院时间(<0.001),尽管急性普通病房的最后入院时间缩短了(<0.001)。我们的结果表明,姑息治疗在改善临终结局和 OS 方面发挥了作用。然而,目前的姑息治疗模式严重依赖医院资源。未来需要加强社区护理,并建立质量监测系统。