School of Cancer and Pharmaceutical Studies, Translational Oncology & Urology Research (TOUR), King's College London, London, United Kingdom.
Department of Radiation Oncology, Ghent University, Ghent, Belgium.
PLoS One. 2021 Jan 28;16(1):e0243136. doi: 10.1371/journal.pone.0243136. eCollection 2021.
There is an increased awareness of the effect of a bladder cancer diagnosis and its treatments on the mental wellbeing of patients. However, few studies have evaluated the efficacy, feasibility and acceptability of interventions to improve this mental wellbeing. This systematic review is the first phase of the Medical Research Council Framework for developing complex interventions and provides an overview of the published mental wellbeing interventions that could be used to design an intervention specific for BC patients.
This review was conducted in accordance with the PRISMA guidelines in January 2019 and studies were identified by conducting searches for Medline, the Cochrane Central Register of Controlled Trials and Ovid Gateway. All included studies met the following criteria: mental wellbeing interventions of adults with medically confirmed diagnosis of any type of urological cancer, reported outcomes for specific HRQoL domains including psychological factors. The quality of evidence was assessed according to Down and Black 27-item checklist.
A total of 15,094 records were collected from the literature search and 10 studies matched the inclusion and exclusion criteria. Of these, nine interventions were for patients with prostate cancer and one for patients with kidney cancer. No studies were found for other urological cancers. Depression was the most commonly reported endpoint measured. Of the included studies with positive efficacy, three were group interventions and two were couple interventions. In the group interventions, all showed a reduction in depressive symptoms and in the couple interventions, there was a reduction in depressive symptoms and a favourable relationship cohesion. The couple interventions were the most feasible and acceptable, but further research was required for most of the studies.
While awareness of the importance of mental wellbeing in bladder cancer patients is growing, this systematic literature review highlights the gap of feasible and acceptable interventions for this patient population.
人们越来越意识到膀胱癌诊断及其治疗对患者心理健康的影响。然而，很少有研究评估改善这种心理健康的干预措施的疗效、可行性和可接受性。本系统评价是医学研究理事会制定复杂干预措施框架的第一阶段，它概述了可用于为 BC 患者设计特定干预措施的已发表的心理健康干预措施。
本研究于 2019 年 1 月按照 PRISMA 指南进行，通过检索 Medline、Cochrane 对照试验中心注册库和 Ovid 网关来确定研究。所有纳入的研究均符合以下标准：针对经医学确认患有任何类型泌尿系统癌症的成年人的心理健康干预措施，报告了特定 HRQoL 领域（包括心理因素）的结果。根据 Down 和 Black 27 项清单评估证据质量。
从文献检索中总共收集了 15094 条记录，有 10 项研究符合纳入和排除标准。其中，9 项干预措施针对前列腺癌患者，1 项针对肾癌患者。未发现其他泌尿系统癌症的研究。抑郁是最常报告的测量终点。在具有积极疗效的纳入研究中，有 3 项是小组干预，2 项是夫妻干预。在小组干预中，所有研究均显示抑郁症状减轻，而在夫妻干预中，抑郁症状减轻，夫妻关系更加紧密。夫妻干预措施最可行和最容易接受，但大多数研究仍需要进一步研究。
虽然人们越来越意识到膀胱癌患者心理健康的重要性，但本系统文献综述突出了针对这一患者群体的可行且可接受的干预措施的差距。
