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雷贝拉唑通过调节小肠微生物群改善了消炎痛引起的小肠损伤和质子泵抑制剂加重的这种损伤。

Rebamipide ameliorates indomethacin-induced small intestinal damage and proton pump inhibitor-induced exacerbation of this damage by modulation of small intestinal microbiota.

机构信息

Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Department of Gastroenterology, Osaka City Juso Hospital, Osaka, Japan.

出版信息

PLoS One. 2021 Jan 28;16(1):e0245995. doi: 10.1371/journal.pone.0245995. eCollection 2021.

DOI:10.1371/journal.pone.0245995
PMID:33507971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7842908/
Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) induce small intestinal damage. It has been reported that rebamipide, a mucoprotective drug, exerts a protective effect against NSAID-induced small intestinal damage; however, the underlying mechanism remains unknown. In this study, we investigated the significance of the small intestinal microbiota in the protective effect of rebamipide against indomethacin-induced small intestinal damage in mice. A comprehensive analysis of the 16S rRNA gene sequencing revealed an alteration in the composition of the small intestinal microbiota at the species level, modulated by the administration of rebamipide and omeprazole. The transplantation of the small intestinal microbiota of the mice treated with rebamipide suppressed the indomethacin-induced small intestinal damage. Omeprazole, a proton pump inhibitor, exacerbated the indomethacin-induced small intestinal damage, which was accompanied by the alteration of the small intestinal microbiota. We found that the transplantation of the small intestinal microbiota of the rebamipide-treated mice ameliorated indomethacin-induced small intestinal damage and the omeprazole-induced exacerbation of the damage. These results suggest that rebamipide exerts a protective effect against NSAID-induced small intestinal damage via the modulation of the small intestinal microbiota, and that its ameliorating effect extends also to the exacerbation of NSAID-induced small intestinal damage by proton pump inhibitors.

摘要

非甾体抗炎药（NSAIDs）会导致小肠损伤。有报道称，黏膜保护剂瑞巴派特对 NSAIDs 诱导的小肠损伤具有保护作用，但具体机制尚不清楚。在这项研究中，我们研究了小肠微生物群在瑞巴派特对吲哚美辛诱导的小鼠小肠损伤的保护作用中的意义。16S rRNA 基因测序的综合分析表明，瑞巴派特和奥美拉唑给药可调节小肠微生物群在物种水平上的组成发生改变。瑞巴派特处理小鼠的小肠微生物群移植可抑制吲哚美辛诱导的小肠损伤。质子泵抑制剂奥美拉唑加剧了吲哚美辛诱导的小肠损伤，同时改变了小肠微生物群。我们发现，瑞巴派特处理小鼠的小肠微生物群移植可改善吲哚美辛诱导的小肠损伤和奥美拉唑诱导的损伤加重。这些结果表明，瑞巴派特通过调节小肠微生物群发挥对 NSAIDs 诱导的小肠损伤的保护作用，其改善作用还延伸至质子泵抑制剂加重 NSAIDs 诱导的小肠损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29d2/7842908/fac6fc623bf5/pone.0245995.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29d2/7842908/e68a0ad7546e/pone.0245995.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29d2/7842908/8132f7f8c356/pone.0245995.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29d2/7842908/91f9b0adfb36/pone.0245995.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29d2/7842908/53d6092a6740/pone.0245995.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29d2/7842908/0d5834d633c4/pone.0245995.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29d2/7842908/fac6fc623bf5/pone.0245995.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29d2/7842908/e68a0ad7546e/pone.0245995.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29d2/7842908/8132f7f8c356/pone.0245995.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29d2/7842908/91f9b0adfb36/pone.0245995.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29d2/7842908/53d6092a6740/pone.0245995.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29d2/7842908/0d5834d633c4/pone.0245995.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29d2/7842908/fac6fc623bf5/pone.0245995.g006.jpg

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