Yuan Chao, Wang Xue, Shang Ying, Chen Xiangdong, Xu Hui, Zhang Zhen
Department of Skin & Cosmetic Research, Shanghai Skin Disease Hospital, Shanghai, 200050, China.
Department of Dermatology, Shanghai Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200001, China.
Lasers Surg Med. 2021 Oct;53(8):1050-1058. doi: 10.1002/lsm.23380. Epub 2021 Jan 28.
To compare changes in skin sensitivity before and after treatment with a 1064-nm Q-switched Nd:YAG laser in healthy individuals, and to provide a reference for clinicians to use this laser reasonably.
STUDY DESIGN/MATERIALS AND METHODS: Nineteen healthy female volunteers underwent 10 random unilateral 1064-nm Q-switched Nd:YAG laser treatments. The skin transepidermal water loss rate (TEWL), skin glossiness, epidermal and dermal thickness and density, current perception threshold (CPT) value, facial blood perfusion were determined before and after treatment at different time points. Moreover, the changes in skin barrier function, blood vessels, and sensory nerve reaction in the treated and untreated sides of the face were recorded before and after treatment.
Seventeen volunteers completed the 12-month follow-up study after 1064-nm Q-switched Nd:YAG laser treatment. At D3, M3, and M6, skin TEWL was decreased on the treated side of the face. Skin glossiness was significantly improved in the early post-treatment period (D1-D7) and M3, M6, and M12 compared with the untreated side of the face. There was no significant change in dermal and epidermal thickness or density at all time points before and after treatment. There were no significant differences in sensory nerve CPT values and local blood flow volume or velocity between the treated side of the face and the untreated side before and after treatment.
Multiple low-energy 1064-nm Q-switched Nd:YAG laser treatments will not affect the barrier function of facial skin, skin nerve sensitivity, or local microcirculation of healthy skin over the long term. Therefore, 1064-nm Q-switched Nd:YAG laser treatment is safe, and does not alter skin sensitivity. Lasers Surg. Med. © 2021 Wiley Periodicals LLC.
比较健康个体接受1064nm调Q Nd:YAG激光治疗前后皮肤敏感性的变化，为临床医生合理使用该激光提供参考。
研究设计/材料与方法：19名健康女性志愿者接受10次随机单侧1064nm调Q Nd:YAG激光治疗。在不同时间点治疗前后测定皮肤经表皮水分流失率（TEWL）、皮肤光泽度、表皮和真皮厚度及密度、电流感觉阈值（CPT）值、面部血液灌注。此外，记录治疗前后面部治疗侧和未治疗侧皮肤屏障功能、血管及感觉神经反应的变化。
17名志愿者在接受1064nm调Q Nd:YAG激光治疗后完成了12个月的随访研究。在D3、M3和M6时，治疗侧面部皮肤TEWL降低。与未治疗侧面部相比，治疗后早期（D1 - D7）以及M3、M6和M12时皮肤光泽度显著改善。治疗前后所有时间点真皮和表皮厚度及密度均无显著变化。治疗前后面部治疗侧与未治疗侧之间感觉神经CPT值、局部血流量或血流速度均无显著差异。
多次低能量1064nm调Q Nd:YAG激光治疗长期不会影响健康面部皮肤的屏障功能、皮肤神经敏感性或局部微循环。因此，1064nm调Q Nd:YAG激光治疗是安全的，且不会改变皮肤敏感性。《激光外科与医学》。©2021威利期刊有限责任公司。
