Jun Hee Jin, Kim So Min, Choi Won Joon, Cho Sang Hyun, Lee Jeong Deuk, Kim Hei Sung
Department of Dermatology, Incheon St. Mary's Hospital, The Catholic University of Korea , Incheon , Republic of Korea.
J Cosmet Laser Ther. 2014 Apr;16(2):83-8. doi: 10.3109/14764172.2013.877749. Epub 2014 Feb 10.
Asians are prone to develop epidermal pigmentary lesions as a result of photoaging. Solar lentigines, especially those which are light in color, show somewhat limited response to pigment lasers and intense pulsed light sources.
We sought to compare the early effects as well as side effects of Q-switched Nd:YAG and Er:YAG micropeel in treating light solar lentigines in Asians.
This was a split-face, evaluator-blind, randomized controlled study. A single session of treatment was performed on Asian patients with light facial lentigines. Q-switched Nd:YAG laser was allocated to one half of the face, and Er:YAG micropeel to the other half. The response to therapy was evaluated by two independent dermatologists with standardized photographs taken 2 weeks and 1 month after the laser treatment. Patients' satisfaction and preference in treatment were also assessed.
Fifteen patients completed the study and were analyzed. A reduction in pigment was observed with both lasers during the study period. The degree of pigment reduction in the Q-switched Nd:YAG treated side of the face was significantly higher than that of the Er:YAG micropeel treated side at 2-week follow-up (p < 0.001). The degree of pigment reduction between the Q-switched Nd:YAG-treated side and the Er:YAG micropeel-treated side was similar at 1-month follow-up (p = 0.110).
While there is no perfect therapy for light solar lentigines, a single session of Q-switched Nd:YAG laser and Er:YAG micropeel was shown to reduce pigmentation. The immediate effects (2-week follow-up) were better with the Q-switched Nd:YAG laser but there was no great difference between the two laser types at 1-month follow-up due to the greater degree of post-inflammatory hyperpigmentation following Q-switched Nd:YAG. Both laser types could be applied either singly in turns, or in combination for maximal efficacy in future.
由于光老化，亚洲人更容易出现表皮色素沉着病变。日光性雀斑，尤其是颜色较浅的那些，对色素激光和强脉冲光源的反应有限。
我们试图比较调Q Nd:YAG激光和铒激光微剥脱术治疗亚洲人浅色日光性雀斑的早期效果和副作用。
这是一项半脸、评估者盲法、随机对照研究。对患有面部浅色雀斑的亚洲患者进行单次治疗。调Q Nd:YAG激光用于半侧面部，铒激光微剥脱术用于另一侧面部。由两名独立的皮肤科医生通过激光治疗后2周和1个月拍摄的标准化照片评估治疗反应。还评估了患者对治疗的满意度和偏好。
15名患者完成研究并进行分析。在研究期间，两种激光治疗后色素均有减少。在2周随访时，调Q Nd:YAG激光治疗侧面部的色素减少程度明显高于铒激光微剥脱术治疗侧（p < 0.001）。在1个月随访时，调Q Nd:YAG激光治疗侧和铒激光微剥脱术治疗侧的色素减少程度相似（p = 0.110）。
虽然对于浅色日光性雀斑没有完美的治疗方法，但单次调Q Nd:YAG激光和铒激光微剥脱术可减少色素沉着。调Q Nd:YAG激光的即时效果（2周随访）更好，但由于调Q Nd:YAG激光后炎症后色素沉着程度较高，两种激光类型在1个月随访时差异不大。两种激光类型今后可单独交替应用，或联合应用以达到最大疗效。
