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Trifluridine/tipiracil versus placebo in patients with heavily pretreated metastatic gastric cancer (TAGS): a randomised, double-blind, placebo-controlled, phase 3 trial.替氟尿苷/替匹嘧啶对比安慰剂用于既往大量治疗的转移性胃癌患者(TAGS):一项随机、双盲、安慰剂对照的 3 期临床试验。
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[Long-Term Survivor with Recurrent Gastric Cancer Using Trifluridine/Tipiracil as a Late-Line Chemotherapy].[使用曲氟尿苷/替匹嘧啶作为晚期化疗方案的复发性胃癌长期存活者]
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Rapidly Evolving Treatment Landscape for Metastatic Esophagogastric Carcinoma: Review of Recent Data.转移性食管胃癌快速演变的治疗格局:近期数据综述
Onco Targets Ther. 2021 Aug 5;14:4361-4381. doi: 10.2147/OTT.S216047. eCollection 2021.

本文引用的文献

1
FOLFIRI plus ramucirumab versus paclitaxel plus ramucirumab as second-line therapy for patients with advanced or metastatic gastroesophageal adenocarcinoma with or without prior docetaxel - results from the phase II RAMIRIS Study of the German Gastric Cancer Study Group at AIO.FOLFIRI联合雷莫西尤单抗对比紫杉醇联合雷莫西尤单抗作为晚期或转移性胃食管腺癌患者的二线治疗(无论是否接受过多西他赛治疗)——德国胃癌研究组AIO的II期RAMIRIS研究结果
Eur J Cancer. 2022 Apr;165:48-57. doi: 10.1016/j.ejca.2022.01.015. Epub 2022 Feb 21.
2
Safety and activity of trifluridine/tipiracil and ramucirumab in previously treated advanced gastric cancer: an open-label, single-arm, phase 2 trial.替氟尿苷/盐酸替匹嘧啶与雷莫芦单抗治疗既往治疗的晚期胃癌的安全性和活性:一项开放标签、单臂、Ⅱ期临床试验。
Lancet Gastroenterol Hepatol. 2021 Mar;6(3):209-217. doi: 10.1016/S2468-1253(20)30396-4. Epub 2021 Jan 26.
3
Treatment after progression in the era of immunotherapy.免疫治疗时代的进展后治疗。
Lancet Oncol. 2020 Oct;21(10):e463-e476. doi: 10.1016/S1470-2045(20)30328-4.
4
PD-1 regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer.PD-1 阻断扩增的 PD-1 调节性 T 细胞促进癌症的过度进展。
Proc Natl Acad Sci U S A. 2019 May 14;116(20):9999-10008. doi: 10.1073/pnas.1822001116. Epub 2019 Apr 26.
5
Initial Report of Second-Line FOLFIRI in Combination with Ramucirumab in Advanced Gastroesophageal Adenocarcinomas: A Multi-Institutional Retrospective Analysis.二线 FOLFIRI 联合雷莫芦单抗治疗晚期胃食管腺癌的初步报告:多机构回顾性分析。
Oncologist. 2019 Apr;24(4):475-482. doi: 10.1634/theoncologist.2018-0602. Epub 2018 Nov 23.
6
Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8 T cells in the tumor microenvironment.雷莫芦单抗靶向 VEGFR2 强烈影响肿瘤微环境中的效应器/激活调节性 T 细胞和 CD8 T 细胞。
J Immunother Cancer. 2018 Oct 11;6(1):106. doi: 10.1186/s40425-018-0403-1.
7
Subgroup analyses of the safety and efficacy of ramucirumab in Japanese and Western patients in RAINBOW: a randomized clinical trial in second-line treatment of gastric cancer.RAINBOW研究中雷莫西尤单抗在日本和西方患者中的安全性和疗效亚组分析:一项胃癌二线治疗的随机临床试验
Gastric Cancer. 2016 Jul;19(3):927-38. doi: 10.1007/s10120-015-0559-z. Epub 2015 Oct 28.

Trifluridine/tipiracil plus ramucirumab in gastric cancer.

作者信息

Zhu Mojun, Sonbol Mohamad Bassam, Yoon Harry H

机构信息

Mayo Clinic, Rochester, MN 55905, USA.

Mayo Clinic, Phoenix, AZ, USA.

出版信息

Lancet Gastroenterol Hepatol. 2021 Mar;6(3):154-155. doi: 10.1016/S2468-1253(21)00013-3. Epub 2021 Jan 26.

DOI:10.1016/S2468-1253(21)00013-3
PMID:33508243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8447873/
Abstract
摘要