荧蒽在灌流肝细胞中生物转化的异质性。
Heterogeneity of biotransformation of fluoranthene in perifused liver cells.
作者信息
Stier A, Schlenker A, Sidhu J, Kühnle W, Finch S A
机构信息
Max-Planck-Institut for Biophysical Chemistry, Göttingen, Federal Republic of Germany.
出版信息
J Cancer Res Clin Oncol. 1988;114(1):39-46. doi: 10.1007/BF00390484.
Abstract
Pathways of biotransformation of the carcinogenic polycyclic hydrocarbon fluoranthene in individual isolated perifused liver cells were delineated using noninvasive microfluorescence spectroscopic techniques. An example of heterogeneity of coupling between phase I and phase II enzymes detected in a population of beta-naphthoflavone-induced rat liver cells demonstrates the usefulness of the experimental model of perifused liver cells.
摘要
运用非侵入性微荧光光谱技术描绘了致癌多环芳烃荧蒽在单个分离的灌流肝细胞中的生物转化途径。在一组β-萘黄酮诱导的大鼠肝细胞中检测到的I相和II相酶之间偶联的异质性实例证明了灌流肝细胞实验模型的实用性。
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