荧蒽在灌流肝细胞中生物转化的异质性。
Heterogeneity of biotransformation of fluoranthene in perifused liver cells.
作者信息
Stier A, Schlenker A, Sidhu J, Kühnle W, Finch S A
机构信息
Max-Planck-Institut for Biophysical Chemistry, Göttingen, Federal Republic of Germany.
出版信息
J Cancer Res Clin Oncol. 1988;114(1):39-46. doi: 10.1007/BF00390484.
Abstract
Pathways of biotransformation of the carcinogenic polycyclic hydrocarbon fluoranthene in individual isolated perifused liver cells were delineated using noninvasive microfluorescence spectroscopic techniques. An example of heterogeneity of coupling between phase I and phase II enzymes detected in a population of beta-naphthoflavone-induced rat liver cells demonstrates the usefulness of the experimental model of perifused liver cells.
摘要
运用非侵入性微荧光光谱技术描绘了致癌多环芳烃荧蒽在单个分离的灌流肝细胞中的生物转化途径。在一组β-萘黄酮诱导的大鼠肝细胞中检测到的I相和II相酶之间偶联的异质性实例证明了灌流肝细胞实验模型的实用性。
相似文献
1
Heterogeneity of biotransformation of fluoranthene in perifused liver cells.荧蒽在灌流肝细胞中生物转化的异质性。
J Cancer Res Clin Oncol. 1988;114(1):39-46. doi: 10.1007/BF00390484.
2
Metabolic activation of dibenzo(a,e)fluoranthene, a nonalternant carcinogenic polycyclic hydrocarbon, in liver homogenates.
Cancer Res. 1980 May;40(5):1742-9.
3
Biotransformation of ketamine in terminal in vivo experiments under chronic intermittent hypoxia conditions and the role of AhR.慢性间歇性缺氧条件下氯胺酮在终末体内实验中的生物转化及芳烃受体的作用
Arch Toxicol. 2025 Apr 19. doi: 10.1007/s00204-025-04044-w.
4
A Comparative Study of Phase I and II Hepatic Microsomal Biotransformation of Phenol in Three Species of Salmonidae: Hydroquinone, Catechol, and Phenylglucuronide Formation.三种鲑科鱼类肝脏微粒体对苯酚的Ⅰ相和Ⅱ相生物转化的比较研究：对苯二酚、儿茶酚和苯基葡萄糖醛酸苷的形成
Fishes. 2024 Jul 17;9(7):1-20. doi: 10.3390/fishes9070284.
5
In vivo and in vitro binding of 1,2-dibromoethane and 1,2-dichloroethane to macromolecules in rat and mouse organs.1,2 - 二溴乙烷和1,2 - 二氯乙烷在大鼠和小鼠器官中与大分子的体内及体外结合
J Cancer Res Clin Oncol. 1984;108(2):204-13. doi: 10.1007/BF00402468.
6
Chain length and chlorine position affect biotransformation of chlorinated paraffins in an in vitro hepatic model.链长和氯原子位置对体外肝脏模型中氯化石蜡的生物转化有影响。
J Hazard Mater. 2025 Aug 15;494:138746. doi: 10.1016/j.jhazmat.2025.138746. Epub 2025 May 26.
7
Multi-step metabolism of the carcinogen dibenzo[a,e]fluoranthene. I. Identification of the metabolites from rat microsomes.
Carcinogenesis. 1983;4(7):827-35. doi: 10.1093/carcin/4.7.827.
8
Influence of a prolonged treatment with disulfiram and D(-)penicillamine on nitrosodiethylamine-induced biological and biochemical effects in rats. I. Investigations on the drug metabolizing system.双硫仑和D(-)青霉胺长期治疗对大鼠亚硝基二乙胺诱导的生物学和生化效应的影响。I. 对药物代谢系统的研究。
J Cancer Res Clin Oncol. 1985;109(1):9-15. doi: 10.1007/BF01884248.
9
Experimental investigations into the carcinogenic effect of antitumor and immunosuppressive agents.抗肿瘤和免疫抑制剂致癌作用的实验研究。
J Cancer Res Clin Oncol. 1989;115(4):309-28. doi: 10.1007/BF00400957.
10
Study of the biotransformation of benfluron using the isolated perfused rat liver.
Acta Medica (Hradec Kralove). 1999;42(2):73-8.
本文引用的文献
1
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.肝微粒体的一氧化碳结合色素。II. 增溶、纯化及性质
J Biol Chem. 1964 Jul;239:2379-85.
2
Toxicological studies of liver cells by microspectrofluorometry.利用显微分光荧光测定法对肝细胞进行毒理学研究。
Arch Toxicol. 1980 Mar;44(1-3):45-54. doi: 10.1007/BF00303182.
3
Identification of the mutagenic metabolites of fluoranthene, 2-methylfluoranthene, and 3-methylfluoranthene.荧蒽、2-甲基荧蒽和3-甲基荧蒽的诱变代谢物的鉴定。
Carcinogenesis. 1982;3(8):841-6. doi: 10.1093/carcin/3.8.841.
4
Dynamics of the localization of drug metabolizing enzymes in tissues and cells.
Biochem Soc Trans. 1984 Feb;12(1):60-2. doi: 10.1042/bst0120060.
5
Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay.在新生小鼠肺腺瘤生物测定中荧蒽的致瘤性。
Carcinogenesis. 1984 Oct;5(10):1311-6. doi: 10.1093/carcin/5.10.1311.
6
Glucuronidation of 7-hydroxycoumarin in periportal and pericentral regions of the liver lobule.7-羟基香豆素在肝小叶门周区和中央周围区的葡萄糖醛酸化作用。
Mol Pharmacol. 1984 May;25(3):487-93.
7
Intralobular distribution of UDP-glucuronosyltransferase in livers from untreated, 3-methylcholanthrene- and phenobarbital-treated rats.
Chem Biol Interact. 1984 Feb;48(2):181-90. doi: 10.1016/0009-2797(84)90119-4.
8
1,1,1-Trichloropropene-2,3-oxide: an alternate mechanism for its inhibition of cytochrome P-450.
Res Commun Chem Pathol Pharmacol. 1982 Jan;35(1):111-20.
9
Preparation of rat liver cells. II. Effects of ions and chelators on tissue dispersion.大鼠肝细胞的制备。II. 离子和螯合剂对组织分散的影响。
Exp Cell Res. 1973 Jan;76(1):25-30. doi: 10.1016/0014-4827(73)90414-x.
10
Microsomal activation of fluoranthene to mutagenic metabolites.
Toxicol Appl Pharmacol. 1986 Sep 30;85(3):355-66. doi: 10.1016/0041-008x(86)90343-1.
Zotero 插件