Nickers P, Oosters L, Brasseur F, Kunkler I, Maisin H, Deckers C
Université Catholique de Louvain, Laboratoire de Cancérologie Expérimentale, UCL 5470, Brussels, Belgium.
J Cancer Res Clin Oncol. 1988;114(1):81-6. doi: 10.1007/BF00390489.
The reduction in size of four experimental tumours (ISIS 130 and ISIS 208 immunocytomas, S 437 mammary adenocarcinoma, S 447 colon adenocarcinoma) was investigated in LOU rats under the influence of cytostatic agents belonging to different classes (5-fluorouracil, methotrexate, vinblastine, cisplatin, doxorubicin, cyclophosphamide). External tumour and rectal temperatures were measured at the same time, twice daily, during the whole experiment. With the rectal temperature of the rats kept constant, the reduction in tumour dimensions following chemotherapy correlated via a linear relationship with the duration and degree of tumour hypothermia for the three tumours S 437, ISIS 208, ISIS 130. However, for the same reduction in tumour volume following chemotherapy, the duration and degree of transient tumour hypothermia varied according to the type of tumour and cytostatic agent studied. There was not correlation between the decrease in size of S 447 and external tumour hypothermia. Even when the reduction in tumour size was statistically significant, the hypothermic tumour phase after drug administration was not sufficient to be significant, except for vinblastine. However, the temperature of this slowly growing tumour before chemotherapy was particularly low. The measurement of the degree and duration of external tumour hypothermia of tumours following chemotherapy would represent a new physiological technique for measuring the efficacy and duration of action of cytostatic agents.
在不同种类的细胞抑制剂（5-氟尿嘧啶、甲氨蝶呤、长春碱、顺铂、阿霉素、环磷酰胺）影响下，对LOU大鼠体内4种实验性肿瘤（ISIS 130和ISIS 208免疫细胞瘤、S 437乳腺腺癌、S 447结肠腺癌）的大小缩减情况进行了研究。在整个实验过程中，每天两次同时测量肿瘤外部温度和直肠温度。在大鼠直肠温度保持恒定的情况下，对于S 437、ISIS 208、ISIS 130这三种肿瘤，化疗后肿瘤尺寸的缩减与肿瘤体温过低的持续时间和程度呈线性相关。然而，对于化疗后相同的肿瘤体积缩减情况，短暂性肿瘤体温过低的持续时间和程度会因所研究的肿瘤类型和细胞抑制剂类型而有所不同。S 447肿瘤大小的减小与肿瘤外部体温过低之间没有相关性。即使肿瘤大小的缩减具有统计学意义，除长春碱外，给药后的体温过低肿瘤期也不足以达到显著水平。然而，这种生长缓慢的肿瘤在化疗前的温度特别低。测量化疗后肿瘤外部体温过低的程度和持续时间将代表一种用于测量细胞抑制剂疗效和作用持续时间的新的生理学技术。
