Nickers P, Oosters L, Brasseur F, Deckers-Passau L, Deckers C
Eur J Cancer Clin Oncol. 1986 Apr;22(4):381-5. doi: 10.1016/0277-5379(86)90102-1.
Two transplanted rat immunocytomas with different degrees of sensitivity to single injection of cyclophosphamide (CY) were used to assess the reliability of recording of the tumoral and rectal temperatures may be useful to evaluate the efficacy of cytostatic drugs against experimental rat tumors. With the highly sensitive tumor (ISIS 130), 25 mg/m2 of CY resulted in a pronounced tumor inhibition (Treated/Control tumors = 28%); with the less sensitive (ISIS 208), a CY dose of 320 mg/m2 was necessary to inhibit tumor growth to the same extent. The more important the decrease in tumor size was, after the administration of the drug, the larger the decrease was in tumoral temperature. Since the rectal temperature remained fairly stable, there was an increase of the difference between the tumoral and rectal temperatures. From the comparison between the results obtained for the two tumors with a wide range of CY doses, it appeared that the decrease in tumoral temperature did not correlate with the drug dose itself, but with the actual antitumor efficacy of the drug in each particular case.
选用两只对单次注射环磷酰胺（CY）敏感度不同的移植大鼠免疫细胞瘤，来评估记录肿瘤温度和直肠温度的可靠性，这可能有助于评估细胞毒性药物对实验大鼠肿瘤的疗效。对于高敏肿瘤（ISIS 130），25 mg/m² 的CY可导致明显的肿瘤抑制（治疗组/对照组肿瘤 = 28%）；对于低敏肿瘤（ISIS 208），则需要320 mg/m² 的CY剂量才能将肿瘤生长抑制到相同程度。给药后肿瘤大小的减小越显著，肿瘤温度的降低就越大。由于直肠温度保持相当稳定，肿瘤温度与直肠温度之间的差值增大。通过比较两种肿瘤在广泛CY剂量下获得的结果，发现肿瘤温度的降低与药物剂量本身无关，而是与每种特定情况下药物的实际抗肿瘤疗效相关。
