McArdle H J, Tysoe J
Raine Centre for the Study of Perinatal and Developmental Biology, University of Western Australia, Nedlands, W.A. 6009.
J Cell Physiol. 1988 Mar;134(3):509-13. doi: 10.1002/jcp.1041340326.
The effect of nicotine on transferrin and iron transport in placental cells has been studied. Nicotine inhibits iron uptake but has little effect on the steady-state levels of transferrin. The effect is temperature and concentration dependent and is not reversible. At a concentration of 15 mM nicotine inhibited transferrin endocytosis by 40%, while iron uptake was decreased by nearly 60%. Nicotine exerted a similar effect on reticulocytes, but other amines, either tertiary or quaternary, had little or no effect on either iron uptake or steady-state intracellular transferrin levels. The results suggest that nicotine acts by blocking uptake, probably by acting as a weak base inhibiting iron release from transferrin, and inhibiting exocytosis with a resultant block of endocytosis. The concentrations required to exert an effect are too high to implicate inhibition of iron transport in the effects of smoking on pregnancy.
已对尼古丁对胎盘细胞中转铁蛋白和铁转运的影响进行了研究。尼古丁抑制铁摄取，但对转铁蛋白的稳态水平影响很小。这种影响取决于温度和浓度，且不可逆。在浓度为15 mM时，尼古丁使转铁蛋白内吞作用降低40%，而铁摄取减少近60%。尼古丁对网织红细胞有类似作用，但其他胺类，无论是叔胺还是季胺，对铁摄取或细胞内转铁蛋白稳态水平几乎没有影响。结果表明，尼古丁可能通过作为一种弱碱抑制转铁蛋白释放铁来阻断摄取，并抑制胞吐作用，从而导致内吞作用受阻。产生作用所需的浓度过高，无法将吸烟对妊娠的影响归因于铁转运的抑制。
