Princess Alexandra Hospital, Woolloongabba, Queensland, Australia; University of Queensland, St Lucia, Queensland, Australia.
Princess Alexandra Hospital, Woolloongabba, Queensland, Australia; University of Queensland, St Lucia, Queensland, Australia; Mater Centre for Neurosciences, Mater Hospital, Brisbane, Australia.
J Neuroimmunol. 2021 Mar 15;352:577492. doi: 10.1016/j.jneuroim.2021.577492. Epub 2021 Jan 21.
SOX1 antibodies are generally associated with small cell lung cancer and anti-Hu antibody overlap is common. This case demonstrates isolated anti-SOX1 antibodies with an uncommon tumor type, and relapse of a paraneoplastic syndrome with recurrence of tumor.
We describe a case of a 65-year-old male with a paraneoplastic peripheral neuropathy and anti-SOX1 antibody positivity in the context of a prior male breast Grade 2 ductal carcinoma, in remission at the time of the initial neurological presentation.
Treatment response to intravenous immunoglobulin (IVIg) was demonstrated. After period of clinical stability on IVIg in the context of remission of breast carcinoma, the patient experienced a relapse of his neuropathy. This was associated with tumor recurrence and again responded to tumor excision, radiotherapy and IVIg.
Male breast carcinoma has not previously been associated with anti-SOX1 antibody positive paraneoplastic neuropathy.
SOX1 抗体通常与小细胞肺癌相关，抗 Hu 抗体重叠较为常见。本病例表现为一种罕见肿瘤类型的孤立性抗 SOX1 抗体，以及副肿瘤综合征的复发和肿瘤的复发。
我们描述了一例 65 岁男性的病例，其患有副肿瘤性周围神经病和抗 SOX1 抗体阳性，此前曾患有男性乳腺 2 级导管癌，在最初神经表现时处于缓解期。
静脉注射免疫球蛋白（IVIg）治疗有反应。在乳腺癌缓解期 IVIg 治疗期间临床稳定一段时间后，患者出现了神经病的复发。这与肿瘤复发有关，再次通过肿瘤切除、放疗和 IVIg 治疗有反应。
男性乳腺癌以前与抗 SOX1 抗体阳性的副肿瘤性周围神经病无关。
