Duarte B, Hargis G K, Kukreja S C
Department of Medicine, University of Illinois, Chicago 60680.
J Clin Endocrinol Metab. 1988 Mar;66(3):584-7. doi: 10.1210/jcem-66-3-584.
Estrogens have been used to treat the hypercalcemia in primary hyperparathyroidism. Estrogens and progesterone both stimulate PTH secretion from bovine parathyroid tissue. The effects of these agents on PTH secretion from human parathyroid tissue are not known. In this study, we evaluated the effects of 17 beta-estradiol and progesterone on PTH secretion from abnormal parathyroid tissue from seven patients (four adenomas, three hyperplasia). Both estradiol (10(-9)-10(-6) mol/L) and progesterone (10(-7) and 10(-6) mol/L) significantly stimulated PTH secretion in a time- and dose-dependent manner during a 3-h period. These results indicate the need for a careful evaluation of serum PTH levels and other parameters of parathyroid function in estrogen- and/or progesterone-treated patients with primary hyperparathyroidism.
雌激素已被用于治疗原发性甲状旁腺功能亢进症中的高钙血症。雌激素和孕酮均可刺激牛甲状旁腺组织分泌甲状旁腺激素（PTH）。这些药物对人甲状旁腺组织分泌PTH的影响尚不清楚。在本研究中，我们评估了17β-雌二醇和孕酮对7例患者（4例腺瘤，3例增生）异常甲状旁腺组织分泌PTH的影响。在3小时内，雌二醇（10^(-9)-10^(-6) mol/L）和孕酮（10^(-7)和10^(-6) mol/L）均以时间和剂量依赖性方式显著刺激PTH分泌。这些结果表明，对于接受雌激素和/或孕酮治疗的原发性甲状旁腺功能亢进症患者，需要仔细评估血清PTH水平和甲状旁腺功能的其他参数。
