Department of Cardiology, People's Hospital of Baise, Baise, 533000, People's Republic of China.
Department of Cardiology, The Second People's Hospital of Nanning City, The Third Affiliated Hospital of Guangxi Medical University, Nanning, 530031, People's Republic of China.
Stem Cell Res Ther. 2021 Jan 28;12(1):89. doi: 10.1186/s13287-020-02101-y.
Ischemia-reperfusion injury (IRI) is an important factor limiting the success of cardiac reperfusion therapy. Curcumin has a significant cardioprotective effect against IRI, can inhibit ventricular remodeling induced by pressure load or MI, and improve cardiac function. However, the poor water solubility and low bioavailability of curcumin restrict its clinical application.
In this study, we prepared and evaluated a curcumin-hydrogel (cur-hydrogel) to reduce cardiomyocyte apoptosis and reactive oxygen species formation induced by hypoxia-reoxygenation injury, promote autophagy, and reduce mitochondrial damage by maintaining the phosphorylation of Cx43.
Meanwhile, cur-hydrogel can restore cardiac function, inhibit myocardial collagen deposition and apoptosis, and activate JAK2/STAT3 pathway to alleviate myocardial ischemia-reperfusion injury in rats.
The purpose of this study is to elucidate the protective effects of cur-hydrogel on myocardial ischemia-reperfusion injury by regulating apoptosis, autophagy, and mitochondrial injury in vitro and in vivo, which lays a new theoretical and experimental foundation for the prevention and reduction of IRI.
缺血再灌注损伤（IRI）是限制心脏再灌注治疗成功的重要因素。姜黄素对 IRI 具有显著的心脏保护作用，可抑制压力负荷或 MI 引起的心室重构，改善心功能。然而，姜黄素的水溶性差、生物利用度低限制了其临床应用。
本研究制备并评价了姜黄素水凝胶（cur-hydrogel），以减少缺氧复氧损伤诱导的心肌细胞凋亡和活性氧形成，通过维持 Cx43 的磷酸化促进自噬，减少线粒体损伤。
同时，cur-hydrogel 可恢复心脏功能，抑制心肌胶原沉积和凋亡，激活 JAK2/STAT3 通路，减轻大鼠心肌缺血再灌注损伤。
本研究旨在通过体外和体内调节凋亡、自噬和线粒体损伤来阐明 cur-hydrogel 对心肌缺血再灌注损伤的保护作用，为预防和减少 IRI 奠定了新的理论和实验基础。
