University of Campinas (UNICAMP), Faculty of School Engineering (FEA), Campinas, São Paulo, Brazil.
University of Campinas (UNICAMP), Faculty of School Engineering (FEA), Campinas, São Paulo, Brazil.
Food Res Int. 2021 Jan;139:109796. doi: 10.1016/j.foodres.2020.109796. Epub 2020 Nov 1.
Inflammatory bowel diseases (IBDs), mainly Crohn's disease and ulcerative colitis, are high-prevalent chronic gastrointestinal disorders that may cause an important reduction in life quality. Such diseases are characterized by their immune-mediated inflammatory, oxidative and dysbiotic events, which can lead to important symptoms in patients, such as abdominal pain, bloody diarrhea and body weicght loss. In the last years, alternative natural options have been postulated for the prevention or treatment of IBDs, since common drug therapy may not be well accepted due to recurrent adverse effects and/or partial efficacy. Among those new natural products, agro-industrial byproducts, such as the peel and seed of foods, are emerging as cheap and pro-ecological options, as they are rich in bioactive compounds, such as polyphenols, but also in non-phenolic compounds, like unsaturated fatty acids, dietary fibers and prebiotics, carotenoids, bioactive peptides, and vitamins. In that sense, Latin America is rich in little explored native fruits and vegetables, from which great amounts of byproducts can be produced. Studies have shown that the byproducts from Latin American vegetables, such as passion-fruit (Passiflora edulis), pineapple (Ananas comosus) and pumpkin (Cucurbita spp.), for example, could represent interesting tools against IBDs, judging by the results of in vitro and animal studies. Therefore, the aim of this review is to discuss the potential role of non-phenolic compounds from native Latin American food byproducts in the prevention or treatment of IBDs, by highlighting their anti-inflammatory, anti-oxidative and/or anti-dysbiotic effects.
炎症性肠病（IBD），主要是克罗恩病和溃疡性结肠炎，是高发的慢性胃肠道疾病，可能导致生活质量的重要降低。这些疾病的特征是其免疫介导的炎症、氧化和菌群失调事件，这可能导致患者出现重要症状，如腹痛、血性腹泻和体重减轻。近年来，已经提出了替代的天然选择，用于预防或治疗 IBD，因为常规药物治疗可能由于反复的不良反应和/或部分疗效而不能被很好地接受。在这些新的天然产品中，农业工业副产品，如食品的果皮和种子，作为廉价和生态友好的选择而出现，因为它们富含生物活性化合物，如多酚，以及非酚类化合物，如不饱和脂肪酸、膳食纤维和益生元、类胡萝卜素、生物活性肽和维生素。在这方面，拉丁美洲拥有丰富的未被充分探索的本地水果和蔬菜，从中可以产生大量的副产品。研究表明，来自拉丁美洲蔬菜的副产品，如百香果（Passiflora edulis）、菠萝（Ananas comosus）和南瓜（Cucurbita spp.），例如，可以通过体外和动物研究的结果，代表对抗 IBD 的有趣工具。因此，本综述的目的是讨论来自本地拉丁美洲食物副产品的非酚类化合物在预防或治疗 IBD 中的潜在作用，强调其抗炎、抗氧化和/或抗菌群失调作用。
