Guangxi Key Laboratory for Polysaccharide Materials and Modifications,School of Marine Sciences and Biotechnology, Guangxi University for Nationalities, Nanning 530008, China.
College of Life Science and Technology, Guangxi University, Nanning 530004, China.
Yi Chuan. 2021 Jan 20;43(1):66-73. doi: 10.16288/j.yczz.20-245.
In bacteria, GntR family transcription regulators are the widespread family of transcription factors. Members of this family consist of two functional domains, a conserved N-terminal DNA-binding domain that contains a typical helix-turn-helix (HTH) motif and a C-terminal effector-binding or oligomerization domain. Usually, the amino acid sequences of N-terminal DNA-binding domains are highly conserved, but differ in the C-terminal effector-binding or oligomerization domains. In the past several decades, many GntR family transcription regulators have been characterized in a number of bacteria. These regulators control a variety of cellular processes such as cell motility, glucose metabolism, bacterial resistance, pathogenesis and virulence. In this review, we summarized the discovery, C-terminal domains, biological function and regulation mode of GntR family transcription regulators. This review will help researchers to obtain more knowledge about the functions and mechanisms of the GntR family transcriptional regulatory factors.
在细菌中，GntR 家族转录调控因子是广泛存在的转录因子家族。该家族的成员由两个功能域组成，一个保守的 N 端 DNA 结合域，包含一个典型的螺旋-转角-螺旋（HTH）基序和一个 C 端效应子结合或寡聚化域。通常，N 端 DNA 结合域的氨基酸序列高度保守，但在 C 端效应子结合或寡聚化域中存在差异。在过去的几十年中，许多 GntR 家族转录调控因子在许多细菌中得到了表征。这些调节剂控制着多种细胞过程，如细胞运动、葡萄糖代谢、细菌耐药性、发病机制和毒力。在这篇综述中，我们总结了 GntR 家族转录调控因子的发现、C 端结构域、生物学功能和调控模式。这篇综述将有助于研究人员获得更多关于 GntR 家族转录调节因子的功能和机制的知识。
