Xiong Zhenliang, Tian Chong, Zeng Xianchun, Huang Jie, Wang Rongpin
Department of Radiology, Guizhou Provincial People's Hospital, Guiyang, China.
School of Medicine, Guizhou University, Guiyang, China.
Front Neurosci. 2021 Jan 12;14:592720. doi: 10.3389/fnins.2020.592720. eCollection 2020.
The intrinsic activity of the human brain maintains its general operation at rest, and this ongoing spontaneous activity exhibits a high level of spatiotemporally correlated activity among different cortical areas, showing intrinsically organized brain functional connectivity (FC) networks. Many functional network properties of the human brain have been investigated extensively for both rest and task states, but the relationship between these two states has been rarely investigated yet and remains unclear. Comparing well-defined task-specific networks with corresponding intrinsic FC networks may reveal their relationship and improve our understanding of the brain's operations at both rest and task states. This study investigated the relationship of the sensorimotor and visual cortical FC networks between the resting and task states. The sensorimotor task was to rub right-hand fingers, and the visual task was to open and close eyes, respectively. Our study demonstrated a general relationship of the task-evoked FC network with its corresponding intrinsic FC network, regardless of the tasks. For each task type, the study showed that (1) the intrinsic and task-evoked FC networks shared a common network and the task enhanced the coactivity within that common network compared to the intrinsic activity; (2) some areas within the intrinsic FC network were not activated by the task, and therefore, the task activated only partial but not whole of the intrinsic FC network; and (3) the task activated substantial additional areas outside the intrinsic FC network and therefore recruited more intrinsic FC networks to perform the task.
人类大脑的内在活动维持其在静息状态下的一般运作，这种持续的自发活动在不同皮层区域之间表现出高度的时空相关活动，显示出内在组织的脑功能连接（FC）网络。人类大脑的许多功能网络特性已在静息和任务状态下进行了广泛研究，但这两种状态之间的关系尚未得到充分研究，仍然不清楚。将明确界定的任务特定网络与相应的内在FC网络进行比较，可能会揭示它们之间的关系，并增进我们对大脑在静息和任务状态下运作的理解。本研究调查了静息和任务状态下感觉运动和视觉皮层FC网络之间的关系。感觉运动任务是摩擦右手手指，视觉任务分别是睁开和闭上眼睛。我们的研究表明，无论任务如何，任务诱发的FC网络与其相应的内在FC网络之间存在一般关系。对于每种任务类型，研究表明：（1）内在和任务诱发的FC网络共享一个共同网络，并且与内在活动相比，任务增强了该共同网络内的共同活动；（2）内在FC网络中的一些区域未被任务激活，因此，任务仅激活了内在FC网络的一部分而非全部；（3）任务激活了内在FC网络之外的大量额外区域，因此招募了更多的内在FC网络来执行任务。
