Barnhill R L, Goldberg B, Stenn K S
Dermatopathology Laboratory, Yale University School of Medicine, New Haven, CT.
J Cutan Pathol. 1988 Feb;15(1):36-9. doi: 10.1111/j.1600-0560.1988.tb00513.x.
Proliferation of sweat ducts has been described as a reactive process in a variety of benign and malignant neoplasms and inflammatory conditions in the skin, including scarring alopecia. However, to our knowledge this phenomenon has not been observed in non-scarring alopecia. The following case documents such a proliferation arising in an alopecia consistent with alopecia areata. An 83-year-old female developed progressive, fairly well circumscribed patches of alopecia over a 2-3 year period. Unequivocal scarring was not present. Histopathological examination revealed non-scarring alopecia with miniaturized and telogen follicles and a proliferation of eccrine ductal structures in the reticular dermis. These ductal structures varied in size and degree of cystic dilatation and resembled a primary eccrine neoplasm, such as syringoma. Only minimal focal fibrosis was observed in association with the eccrine proliferation. In summary, this case indicates that eccrine sweat duct proliferation may occur in non-scarring alopecia and must be differentiated from a primary eccrine neoplasm.
在包括瘢痕性秃发在内的各种皮肤良性和恶性肿瘤及炎症性疾病中，汗腺导管增生被描述为一种反应性过程。然而，据我们所知，这种现象在非瘢痕性秃发中尚未被观察到。以下病例记录了在与斑秃相符的秃发中出现的这种增生。一名83岁女性在2至3年期间出现了进行性、边界相当清晰的秃发斑。不存在明确的瘢痕形成。组织病理学检查显示为非瘢痕性秃发，伴有毛囊小型化和休止期毛囊，以及网状真皮中汗腺导管结构的增生。这些导管结构大小不一，囊性扩张程度各异，类似原发性汗腺肿瘤，如汗管瘤。与汗腺增生相关的仅观察到极少的局灶性纤维化。总之，该病例表明汗腺导管增生可能发生在非瘢痕性秃发中，并且必须与原发性汗腺肿瘤相鉴别。
