Tan Timothy, Guitart Joan, Gerami Pedram, Yazdan Pedram
Departments of *Pathology, and †Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL; and ‡Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Am J Dermatopathol. 2017 Sep;39(9):668-671. doi: 10.1097/DAD.0000000000000747.
Eccrine duct dilation (EDD) and syringoma-like sweat duct proliferation have been described as reactive changes occurring in a variety of skin conditions. However, extensive evaluation of EDD in scalp biopsies performed for alopecia has not been performed.
We retrospectively examined 129 cases of cicatricial alopecia (lichen planopilaris, central centrifugal cicatricial alopecia, and discoid lupus erythematosus) and 130 cases of noncicatricial alopecias (androgenetic alopecia, telogen effluvium, and alopecia areata) for the presence of EDD.
Overall, EDD occurred in 4% (5/130) of noncicatricial alopecia (2/43 of androgenetic alopecia, 0/15 of telogen effluvium, 3/72 of alopecia areata) and 35% (45/129) of cicatricial alopecia (10/31 of lichen planopilaris, 17/36 central centrifugal cicatricial alopecia, and 18/62 of discoid lupus erythematosus; P < 0.0001) cases.
EDD can infrequently occur in noncicatricial alopecias; however, the frequency of dilation is significantly increased in cicatricial alopecias. This alteration may be due to compressive or inflammatory effects inherent to the scarring process. The presence of EDD may be a useful adjunctive histopathologic feature in the diagnosis of cicatricial alopecias.
小汗腺导管扩张（EDD）和汗管瘤样汗腺导管增生已被描述为在多种皮肤疾病中出现的反应性改变。然而，对于因脱发而进行的头皮活检中EDD的广泛评估尚未开展。
我们回顾性检查了129例瘢痕性脱发（扁平苔藓样毛发扁平苔藓、中央离心性瘢痕性脱发和盘状红斑狼疮）和130例非瘢痕性脱发（雄激素性脱发、休止期脱发和斑秃）病例，以确定是否存在EDD。
总体而言，EDD发生于4%（5/130）的非瘢痕性脱发（雄激素性脱发中2/43，休止期脱发中0/15，斑秃中3/72）和35%（45/129）的瘢痕性脱发（扁平苔藓样毛发扁平苔藓中10/31，中央离心性瘢痕性脱发中17/36，盘状红斑狼疮中18/62；P<0.0001）病例。
EDD在非瘢痕性脱发中很少见；然而，在瘢痕性脱发中扩张的频率显著增加。这种改变可能是由于瘢痕形成过程中固有的压迫或炎症作用。EDD的存在可能是瘢痕性脱发诊断中一个有用的辅助组织病理学特征。
