Fekete Elena, Allain Thibault, Siddiq Affan, Sosnowski Olivia, Buret Andre G
Department of Biological Sciences, University of Calgary, Calgary, AB, Canada.
Inflammation Research Network, University of Calgary, Calgary, AB, Canada.
Front Microbiol. 2021 Jan 12;11:618106. doi: 10.3389/fmicb.2020.618106. eCollection 2020.
Alteration of the intestinal microbiome by enteropathogens is commonly associated with gastrointestinal diseases and disorders and has far-reaching consequences for overall health. Significant advances have been made in understanding the role of microbial dysbiosis during intestinal infections, including infection with the protozoan parasite , one of the most prevalent gut protozoa. Altered species composition and diversity, functional changes in the commensal microbiota, and changes to intestinal bacterial biofilm structure have all been demonstrated during the course of infection and have been implicated in pathogenesis. Conversely, the gut microbiota has been found to regulate parasite colonization and establishment and plays a critical role in immune modulation during mono and polymicrobial infections. These disruptions to the commensal microbiome may contribute to a number of acute, chronic, and post-infectious clinical manifestations of giardiasis and may account for variations in disease presentation within and between infected populations. This review discusses recent advances in characterizing -induced bacterial dysbiosis in the gut and the roles of dysbiosis in pathogenesis.
肠道病原体对肠道微生物群的改变通常与胃肠道疾病和紊乱相关，并对整体健康产生深远影响。在理解微生物群落失调在肠道感染（包括原生动物寄生虫感染，最常见的肠道原生动物之一）过程中的作用方面已经取得了重大进展。在感染过程中，已证明共生微生物群的物种组成和多样性发生改变、功能变化以及肠道细菌生物膜结构发生变化，并且这些变化与发病机制有关。相反，已发现肠道微生物群可调节寄生虫的定植和建立，并在单一和多种微生物感染期间的免疫调节中起关键作用。共生微生物群的这些破坏可能导致贾第虫病的许多急性、慢性和感染后临床表现，并可能解释感染人群内部和之间疾病表现的差异。本综述讨论了在表征肠道中贾第虫诱导的细菌失调及其在发病机制中的作用方面的最新进展。
