Department of Pharmacy Practice and Center of Excellence for Innovation in Chemistry, Pharmacological Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.
Planta Med. 2021 Aug;87(9):709-715. doi: 10.1055/a-1324-3570. Epub 2021 Jan 28.
Reduction of intestinal glucose absorption might result from either delayed carbohydrate digestion or blockage of glucose transporters. Previously, oxyresveratrol was shown to inhibit -glucosidase, but its effect on glucose transporters has not been explored. The present study aimed to assess oxyresveratrol-induced inhibition of the facilitative glucose transporter 2 and the active sodium-dependent glucose transporter 1. An aqueous extract of Puag Haad, which is oxyresveratrol-enriched, was also investigated. Glucose transport was measured by uptake into Caco-2 cells through either glucose transporter 2 or sodium-dependent glucose transporter 1 according to the culture conditions. Oxyresveratrol (40 to 800 µM) dose-dependently reduced glucose transport, which appeared to inhibit both glucose transporter 2 and sodium-dependent glucose transporter 1. Puag Haad at similar concentrations also inhibited these transporters but with greater efficacy. Oxyresveratrol and Puag Haad could help reduce postprandial hyperglycemic peaks, which are considered to be most damaging in diabetics.
肠道葡萄糖吸收的减少可能是由于碳水化合物消化延迟或葡萄糖转运蛋白受阻所致。先前的研究表明，白藜芦醇能够抑制β-葡萄糖苷酶，但它对葡萄糖转运蛋白的影响尚未得到探索。本研究旨在评估白藜芦醇对易化型葡萄糖转运蛋白 2 和主动钠依赖性葡萄糖转运蛋白 1 的抑制作用。还研究了富含白藜芦醇的 Puag Haad 的水提取物。根据培养条件，通过葡萄糖转运蛋白 2 或钠依赖性葡萄糖转运蛋白 1 将摄取到 Caco-2 细胞中的葡萄糖作为葡萄糖转运进行测量。白藜芦醇（40 至 800µM）呈剂量依赖性地降低葡萄糖转运，这似乎抑制了葡萄糖转运蛋白 2 和钠依赖性葡萄糖转运蛋白 1。在相似浓度下，Puag Haad 也抑制了这些转运蛋白，但效果更强。白藜芦醇和 Puag Haad 可帮助降低餐后高血糖峰值，这在糖尿病患者中被认为是最具破坏性的。
