Department of Otolaryngology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Ear Nose Throat J. 2022 Feb;101(2_suppl):31S-36S. doi: 10.1177/0145561320986060. Epub 2021 Jan 29.
This study compared the cerumen dissolution activities of 7.5% sodium bicarbonate, 5% potassium hydroxide, 10% lactic acid, 3% salicylic acid, 10% glycolic acid, and distilled water.
An in vitro study was conducted with 36 cerumen samples. The cerumenolytic activities of the 6 agents were assessed by recording the degree of cerumen disintegration using digital photography at 15 minutes, 30 minutes, 1 hour, 2 hours, and 12 hours. The undissolved cerumen that remained after 12 hours was removed from the solutions and weighed after drying.
Potassium hydroxide showed the fastest cerumenolytic activity, dissolving a moderate amount of cerumen at 30 minutes, while glycolic acid and salicylic acid caused no visible changes in the cerumen samples. Samples treated with potassium hydroxide and sodium bicarbonate exhibited higher degrees of disintegration compared to samples treated with distilled water (odds ratio and 95% CI: 273.237 [0.203-367 470.4] and 1.129 [0.002-850.341], respectively). The greatest reduction in cerumen weight was associated with the use of sodium bicarbonate; however, this result did not reach statistical significance.
Among the solutions tested, 5% potassium hydroxide showed the fastest dissolution activity, yielding moderate disintegration within only 30 minutes. In terms of residual cerumen weight within 12 hours, all solutions exhibited equivalent effectiveness in the disintegration of cerumen.
本研究比较了 7.5%碳酸氢钠、5%氢氧化钾、10%乳酸、3%水杨酸、10%乙醇酸和蒸馏水对耵聍的溶解活性。
采用体外研究方法，对 36 例耵聍样本进行研究。通过数码摄影记录 15 分钟、30 分钟、1 小时、2 小时和 12 小时时耵聍分解程度，评估 6 种试剂的耵聍溶解活性。12 小时后，将未溶解的耵聍从溶液中取出，干燥后称重。
氢氧化钾的耵聍溶解活性最快，在 30 分钟内溶解了适量的耵聍，而乙醇酸和水杨酸对耵聍样本没有明显变化。与用蒸馏水处理的样本相比，用氢氧化钾和碳酸氢钠处理的样本显示出更高的分解程度（比值比和 95%置信区间：273.237 [0.203-367 470.4] 和 1.129 [0.002-850.341]）。碳酸氢钠导致的耵聍重量减少最大，但这一结果没有达到统计学意义。
在所测试的溶液中，5%氢氧化钾显示出最快的溶解活性，仅 30 分钟即可产生中等程度的分解。就 12 小时内的残余耵聍重量而言，所有溶液在耵聍分解方面均表现出等效的效果。
